Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

Phosphorus Metabolism in Resting and Pregnancy-stimulated Mammary Glands and in Spontaneous Mammary Carcinomas of Mice

S. Albert, R. M. Johnson and Marjorie S. Cohan
S. Albert
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. M. Johnson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marjorie S. Cohan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published October 1951
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

  1. Radioactive phosphorus, as Na2HP32O4, was administered to normal and pregnant female mice and to females bearing mammary gland carcinomas, and the animals were sacrificed at 1, 4, 17, or 48 hours after injection. The mice were of the cancer-susceptible C3H and DBA strains. The amounts of phosphorus and radioactivity were determined in the acid-soluble, phospholipid, phosphoprotein, DNA, and PNA fractions.

  2. The concentration of phosphorus in the DNA fraction of the carcinomas was increased threefold over that found in the resting glands, and twofold over that found in the stimulated glands. On the basis of the findings of other workers, it was concluded that this increased DNA phosphorus concentration denotes increased cellularity rather than increased nuclear concentration.

  3. The concentration of phosphorus in the acid-soluble and PNA fractions of the mammary gland carcinomas more closely resembled that found in the pregnancy-stimulated glands, while that in the phospholipid and phosphoprotein fractions resembled that found in the resting glands.

  4. The uptake of radioactivity in all fractions of the carcinomas, except the acid-soluble, was higher than in resting glands. In all fractions it was lower than in the physiologically stimulated glands.

Footnotes

  • ↵* Supported by grants from the National Cancer Institute, of the National Institutes of Health, Public Health Service, the American Cancer Society, Inc., the S.S. Kresge Foundation, and the Michigan Cancer Foundation.

  • Received April 9, 1951.
  • ©1951 American Association for Cancer Research.
PreviousNext
Back to top
October 1951
Volume 11, Issue 10
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Phosphorus Metabolism in Resting and Pregnancy-stimulated Mammary Glands and in Spontaneous Mammary Carcinomas of Mice
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Phosphorus Metabolism in Resting and Pregnancy-stimulated Mammary Glands and in Spontaneous Mammary Carcinomas of Mice
S. Albert, R. M. Johnson and Marjorie S. Cohan
Cancer Res October 1 1951 (11) (10) 772-776;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Phosphorus Metabolism in Resting and Pregnancy-stimulated Mammary Glands and in Spontaneous Mammary Carcinomas of Mice
S. Albert, R. M. Johnson and Marjorie S. Cohan
Cancer Res October 1 1951 (11) (10) 772-776;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
  • Tissue Structure, Nuclear Organization, and Gene Expression in Normal and Malignant Breast
  • The Prizes
Show more Articles
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement