Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

Observations on Carcinogenesis by 4-Dimethylaminoazobenzene

Paul N. Harris and G. H. A. Clowes
Paul N. Harris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. H. A. Clowes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published July 1952
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

  1. Folic acid at the levels of 0.02 mg and 1.9 mg/kg of diet had no effect on tumor formation or cirrhosis of the liver induced by DAB.

  2. No unequivocal evidence was obtained that strain differences in rats influence susceptibility to DAB.

  3. Tumors developed at the same rate with diets containing 5, 10, and 20 per cent of cottonseed oil.

  4. Tumors developed more slowly with a diet containing 5 per cent of corn oil than with diets containing 10 and 20 per cent of corn oil.

  5. Tumors developed more slowly with a diet containing 20 per cent of olive oil than with diets containing 5 and 10 per cent of olive oil.

  6. On comparing results with the same concentrations of oils, tumor development was found to be slowest with diets containing 5 per cent of corn oil and 20 per cent of olive oil, but was essentially the same for the other concentrations and kinds of oil.

  7. There was no difference in tumor development with diets low in riboflavin and containing 10 per cent and 30 per cent of casein, but it was greatly retarded with a 10 per cent casein diet high in riboflavin.

  8. It appears that liver contains one or more factors other than riboflavin, pyridoxine, and biotin that influenced tumor development.

  9. Thiosalicylic acid at the level of 1 per cent in the diet gave protection against tumor development but had no effect upon cirrhosis.

  10. Thiouracil at the level of 0.05 per cent in the diet gave protection against tumor development and against cirrhosis of the liver. It is thought that this result was not due entirely to lowered intake of the carcinogen.

Footnotes

    • Received December 5, 1951.
    • ©1952 American Association for Cancer Research.
    PreviousNext
    Back to top
    July 1952
    Volume 12, Issue 7
    • Table of Contents
    • Table of Contents (PDF)
    • Index by Author
    • Back Matter (PDF)
    • Editorial Board (PDF)

    Sign up for alerts

    Open full page PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for sharing this Cancer Research article.

    NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

    Enter multiple addresses on separate lines or separate them with commas.
    Observations on Carcinogenesis by 4-Dimethylaminoazobenzene
    (Your Name) has forwarded a page to you from Cancer Research
    (Your Name) thought you would be interested in this article in Cancer Research.
    Citation Tools
    Observations on Carcinogenesis by 4-Dimethylaminoazobenzene
    Paul N. Harris and G. H. A. Clowes
    Cancer Res July 1 1952 (12) (7) 471-479;

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Observations on Carcinogenesis by 4-Dimethylaminoazobenzene
    Paul N. Harris and G. H. A. Clowes
    Cancer Res July 1 1952 (12) (7) 471-479;
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Jump to section

    • Article
    • Info & Metrics
    • PDF
    Advertisement

    Related Articles

    Cited By...

    More in this TOC Section

    • Intersections between Blood Cell Development and Leukemia Genes
    • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
    • Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia
    Show more Articles
    • Home
    • Alerts
    • Feedback
    Facebook  Twitter  LinkedIn  YouTube  RSS

    Articles

    • Online First
    • Current Issue
    • Past Issues
    • Meeting Abstracts

    Info for

    • Authors
    • Subscribers
    • Advertisers
    • Librarians
    • Reviewers

    About Cancer Research

    • About the Journal
    • Editorial Board
    • Permissions
    • Submit a Manuscript
    AACR logo

    Copyright © 2018 by the American Association for Cancer Research.

    Cancer Research Online ISSN: 1538-7445
    Cancer Research Print ISSN: 0008-5472
    Journal of Cancer Research ISSN: 0099-7013
    American Journal of Cancer ISSN: 0099-7374

    Advertisement