Summary
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Radioactive phosphorus, as Na2HP32O4, was administered to virgin and breeder mice of the DBA, DBA—, and C57BL strains, and to pregnant mice of the DBA strain. The mice were sacrificed 1, 4, 17, or 48 hours after the administration of the P32, and the total phosphorus and P32 content of the ovaries, adrenals, thyroids, and pituitary glands were determined.
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Inherited factors influenced the phosphorus content of ovaries, adrenals, and thyroids, the P32 uptake in the ovaries, adrenals, and thyroids, and the weights of all endocrine organs studied.
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The presence of the milk agent was associated with an increase in the weight of the ovaries of the virgins, a decrease in the weight of these glands in breeders, and a decrease in P32 uptake in the ovaries and adrenals of breeder animals. It was also associated with a decrease in the amount of phosphorus in the virgin animal thyroids, and with an increased P32 uptake in virgin animal thyroids. Lastly, it was associated with an increased weight of and an initially decreased P32 uptake in virgin mouse pituitaries.
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The change from the virgin to the breeder state was accompanied by a change in ovarian weight and by an altered P32 uptake in certain organs of DBA, DBA—, and C57BL mice. Pregnancy was accompanied by a moderate increase in endocrine organ weight and by a large increase in P32 uptake in all endocrine glands examined.
Footnotes
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↵* Supported by grants from the National Cancer Institute of the National Institutes of Health, Public Health Service; the American Cancer Society; the S. S. Kresge Foundation; and the Michigan Cancer Foundation.
- Received February 23, 1952.
- ©1952 American Association for Cancer Research.