Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

The Effect of Implanted Tumors on the Oxidation of Formate and of the Methyl Group of Methionine in Mouse Liver

Abraham M. Stein and John W. Mehl
Abraham M. Stein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John W. Mehl
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published November 1958
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

  1. The oxidation of formate in dialyzed mouse liver homogenates has been found to be accelerated by additions of acetaldehyde, as well as hypoxanthine and inosine. The greatest stimulation was obtained with inosine.

  2. The effect of formate concentration on the rate of oxidation has been studied in homogenates optimally supplemented with inosine. Although most of the concentration range can be described by the Michaelis-Menten equation, the data also indicate that generation of hydrogen peroxide becomes limiting at formate concentrations of around 0.1 M.

  3. The oxidation of formate is decreased by 40–50 per cent in fortified homogenates from mice carrying the Ehrlich ascites cell carcinoma.

  4. A decreased rate of oxidation of methionine to formate has been found in liver prisms from tumor-bearing mice as compared with those from normal mice.

Footnotes

  • ↵* Supported by an Institutional Grant from the American Cancer Society and by a research grant from the National Cancer Institute (C-2340), Dept. of Health, Education, and Welfare.

    A preliminary report of part of this work has been published (20).

    Taken from a dissertation by A. M. S. presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy to the Graduate School of the University of Southern California.

  • Received June 2, 1958.
  • ©1958 American Association for Cancer Research.
PreviousNext
Back to top
November 1958
Volume 18, Issue 10
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The Effect of Implanted Tumors on the Oxidation of Formate and of the Methyl Group of Methionine in Mouse Liver
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
The Effect of Implanted Tumors on the Oxidation of Formate and of the Methyl Group of Methionine in Mouse Liver
Abraham M. Stein and John W. Mehl
Cancer Res November 1 1958 (18) (10) 1196-1202;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The Effect of Implanted Tumors on the Oxidation of Formate and of the Methyl Group of Methionine in Mouse Liver
Abraham M. Stein and John W. Mehl
Cancer Res November 1 1958 (18) (10) 1196-1202;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Intersections between Blood Cell Development and Leukemia Genes
  • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
  • Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia
Show more Articles
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement