Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

Electron Microscopic Study of the Shay Chloroleukemia

K. Lapis and L. Benedeczky
K. Lapis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L. Benedeczky
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published September 1967
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

The ultrastructure of the Shay chloroma cells has been studied. The cells were taken from the abdominal tumorous infiltrate of young CB rats intraperitoneally inoculated with Shay's chloroleukemia. The cells were examined daily under the electron microscope between the 5th and 15th day following inoculation. The tumorous tissue was found to contain a single type of cells. The polygonal cells were loosely arranged, without intercellular attaching structures between them. Pseudopodia projecting into the intercellular space and rows of pinocytotic intracellular vesicles pointed to intensive surface activity of the tumor cells. The cells had large nuclei and a comparatively narrow cytoplasmic marginal zone which was rich in homogeneously distributed free ribosomes and polysomes but usually poor in rough-surfaced endoplasmic reticulum. The cytoplasm contained a well-developed Golgi apparatus and a varying amount of pigment granules of the dense-core type. The submicroscopic structure of pigment granules and autophagous vacuoles contained in the cytoplasm of the chloroma cells has been described and intensive acid phosphatase activity has been demonstrated on an ultrastructural level in both cytoplasmic inclusions. Acid phosphatase activity was observed in the elements of the Golgi apparatus as well.

The origin of pigment granules and autophagous vacuoles is discussed. Pigment granules were occasionally found in the intercellular space also. Virus-like particles were observed in the intercellular space as well as in the cavity of large membrane-bounded intracellular vacuoles; they occurred mostly in samples taken from older tumors. These corpuscles had an average diameter of 900 Å, included electron-dense nucleoids, and resembled Bernhard's C-type particles.

Footnotes

    • Received August 15, 1966.
    • Accepted May 2, 1967.
    • ©1967 American Association for Cancer Research.
    PreviousNext
    Back to top
    September 1967
    Volume 27, Issue 9
    • Table of Contents
    • Table of Contents (PDF)
    • Index by Author
    • Back Matter (PDF)
    • Editorial Board (PDF)
    • Front Matter (PDF)

    Sign up for alerts

    Open full page PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for sharing this Cancer Research article.

    NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

    Enter multiple addresses on separate lines or separate them with commas.
    Electron Microscopic Study of the Shay Chloroleukemia
    (Your Name) has forwarded a page to you from Cancer Research
    (Your Name) thought you would be interested in this article in Cancer Research.
    Citation Tools
    Electron Microscopic Study of the Shay Chloroleukemia
    K. Lapis and L. Benedeczky
    Cancer Res September 1 1967 (27) (9) 1544-1564;

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Electron Microscopic Study of the Shay Chloroleukemia
    K. Lapis and L. Benedeczky
    Cancer Res September 1 1967 (27) (9) 1544-1564;
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Jump to section

    • Article
    • Info & Metrics
    • PDF
    Advertisement

    Related Articles

    Cited By...

    More in this TOC Section

    • The Role of Chimeric Paired Box Transcription Factors in the Pathogenesis of Pediatric Rhabdomyosarcoma
    • Tissue Structure, Nuclear Organization, and Gene Expression in Normal and Malignant Breast
    • Laureate Citations
    Show more Articles
    • Home
    • Alerts
    • Feedback
    Facebook  Twitter  LinkedIn  YouTube  RSS

    Articles

    • Online First
    • Current Issue
    • Past Issues
    • Meeting Abstracts

    Info for

    • Authors
    • Subscribers
    • Advertisers
    • Librarians
    • Reviewers

    About Cancer Research

    • About the Journal
    • Editorial Board
    • Permissions
    • Submit a Manuscript
    AACR logo

    Copyright © 2018 by the American Association for Cancer Research.

    Cancer Research Online ISSN: 1538-7445
    Cancer Research Print ISSN: 0008-5472
    Journal of Cancer Research ISSN: 0099-7013
    American Journal of Cancer ISSN: 0099-7374

    Advertisement