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Relation of Thymidine Index to Pulmonary Tumor Response in Mice Receiving Urethan and Other Carcinogens

M. B. Shimkin, T. Sasaki, M. McDonough, R. Baserga, D. Thatcher and R. Wieder
M. B. Shimkin
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T. Sasaki
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M. McDonough
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R. Baserga
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D. Thatcher
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R. Wieder
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DOI:  Published May 1969
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Summary

In strain A mice, urethan, 1 mg/gm body weight, produces a decrease in the thymidine index of the lung within 1 day, with recovery and rebound by 7 days. These events are not seen with 0.25 mg/gm urethan although this dose also produces pulmonary tumors in 100% of strain A mice.

The initial decrease in the thymidine index is seen also with 3-methylcholanthrene and nitrogen mustard, with the nadir at 3 days. Inhibition at 1 day occurs also in strains C3H and C57BL following 1 mg/gm urethan, but the rebound is less than in strain A. Urethan inhibition of labeled cells is accentuated by actinomycin D, cytosine arabinoside, and puromycin; pulmonary carcinogenesis is also slightly inhibited.

It is suggested that the inhibition of DNA synthesis, as manifested by the thymidine index, may represent a toxic side effect rather than a key event in carcinogenesis.

Footnotes

  • ↵1 Supported in part by USPHS research grant CA-10439.

  • Received October 21, 1968.
  • Accepted December 15, 1968.
  • ©1969 American Association for Cancer Research.
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May 1969
Volume 29, Issue 5
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Relation of Thymidine Index to Pulmonary Tumor Response in Mice Receiving Urethan and Other Carcinogens
M. B. Shimkin, T. Sasaki, M. McDonough, R. Baserga, D. Thatcher and R. Wieder
Cancer Res May 1 1969 (29) (5) 994-998;

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Relation of Thymidine Index to Pulmonary Tumor Response in Mice Receiving Urethan and Other Carcinogens
M. B. Shimkin, T. Sasaki, M. McDonough, R. Baserga, D. Thatcher and R. Wieder
Cancer Res May 1 1969 (29) (5) 994-998;
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Cancer Research Online ISSN: 1538-7445
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