Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

Carcinogenicity of N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide in Female Rats

E. Ertürk, S. M. Cohen and George T. Bryan
E. Ertürk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. M. Cohen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
George T. Bryan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published April 1970
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide was fed to 70 female Sprague-Dawley weanling rats at a dosage of 0.199% by weight for 46 weeks, followed by 20 weeks of the control diet. Forty control rats received only ground diet for the entire 66 weeks. Rats were weighed and food consumption was determined biweekly at first and then monthly. With weekly palpation the first mammary tumor was detected at 16 weeks, and tumor incidences are based on the number of rats alive at this time. Every 1 or 2 weeks, 1 rat was sacrificed to determine any early pathological changes of the urinary tract or other internal organs.

Of the 56 rats that survived 16 or more weeks, 52 had tumors with the following organ distribution: 47 mammary tumors (24 fibroadenomas and 23 adenocarcinomas), 6 salivary gland adenocarcinomas, 7 alveolar cell carcinomas of the lung, 2 transitional cell carcinomas of the kidney, 3 skin tumors (squamous cell carcinoma, fibrosarcoma, mastocytoma), 1 small intestinal adenocarcinoma, and 1 splenic lymphosarcoma with hepatic metastases. A systemic lymphoreticular response involving the spleen and lymph nodes was seen in a majority of the rats, and several rats had edema, hemorrhage, and partial destruction of the adrenal gland. No tumors were found in the control rats.

A fibroadenoma, an adenofibroma, and an adenocarcinoma of mammary origin and an adenocarcinoma of salivary gland origin were transplantable to the subcutaneous tissue of female Sprague-Dawley weanling rats with the following incidences of transplantable tumors: 7/24, 4/12, 9/12, and 14/24, respectively. Two of the 9 mammary adenocarcinomas that grew in recipient rats metastasized: one through the abdominal wall and into the liver, the other to the spleen.

Footnotes

  • ↵1 Supported in part by Grant CA-10017 from the National Cancer Institute and by a grant from the Wisconsin Division of the American Cancer Society.

  • ↵2 Medical Scientist Trainee of the National Institute of General Medical Sciences (GM-01932).

  • ↵3 Career Development Awardee of the National Cancer Institute (1-K4-CA-8245-01A1).

  • Received June 6, 1969.
  • Accepted September 19, 1969.
  • ©1970 American Association for Cancer Research.
PreviousNext
Back to top
April 1970
Volume 30, Issue 4
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Carcinogenicity of N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide in Female Rats
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Carcinogenicity of N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide in Female Rats
E. Ertürk, S. M. Cohen and George T. Bryan
Cancer Res April 1 1970 (30) (4) 936-941;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Carcinogenicity of N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide in Female Rats
E. Ertürk, S. M. Cohen and George T. Bryan
Cancer Res April 1 1970 (30) (4) 936-941;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • The Role of Chimeric Paired Box Transcription Factors in the Pathogenesis of Pediatric Rhabdomyosarcoma
  • Tissue Structure, Nuclear Organization, and Gene Expression in Normal and Malignant Breast
  • Laureate Citations
Show more Articles
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement