Summary
Twenty-one patients with advanced epidermoid carcinoma of the head and neck were treated with 24-hr infusions of methotrexate followed by leucovorin rescue repeated at 4-day intervals. Thirteen of the 21 patients responded with a greater than 50% reduction of tumor mass and 7 of the 13 sustained a greater than 75% reduction. The median duration of tumor regression was 16 weeks. In general, toxicity was tolerable. The rationale of this regimen and its comparison with other methotrexate schedules is discussed.
Footnotes
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↵1 Supported by Grant T-430 from the American Cancer Society and USPHS Grant CA-0841.
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↵3 Career Development Awardee of the National Cancer Institute (1-K3-CA-8853-06).
- Received November 26, 1969.
- Accepted February 13, 1970.
- ©1970 American Association for Cancer Research.