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Methotrexate Therapy of Head and Neck Cancer: Improvement in Therapeutic Index by the Use of Leucovorin “Rescue”

R. L. Capizzi, R. C. DeConti, J. C. Marsh and J. R. Bertino
R. L. Capizzi
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R. C. DeConti
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J. C. Marsh
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J. R. Bertino
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DOI:  Published June 1970
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Summary

Twenty-one patients with advanced epidermoid carcinoma of the head and neck were treated with 24-hr infusions of methotrexate followed by leucovorin rescue repeated at 4-day intervals. Thirteen of the 21 patients responded with a greater than 50% reduction of tumor mass and 7 of the 13 sustained a greater than 75% reduction. The median duration of tumor regression was 16 weeks. In general, toxicity was tolerable. The rationale of this regimen and its comparison with other methotrexate schedules is discussed.

Footnotes

  • ↵1 Supported by Grant T-430 from the American Cancer Society and USPHS Grant CA-0841.

  • ↵3 Career Development Awardee of the National Cancer Institute (1-K3-CA-8853-06).

  • Received November 26, 1969.
  • Accepted February 13, 1970.
  • ©1970 American Association for Cancer Research.
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June 1970
Volume 30, Issue 6
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Methotrexate Therapy of Head and Neck Cancer: Improvement in Therapeutic Index by the Use of Leucovorin “Rescue”
R. L. Capizzi, R. C. DeConti, J. C. Marsh and J. R. Bertino
Cancer Res June 1 1970 (30) (6) 1782-1788;

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Methotrexate Therapy of Head and Neck Cancer: Improvement in Therapeutic Index by the Use of Leucovorin “Rescue”
R. L. Capizzi, R. C. DeConti, J. C. Marsh and J. R. Bertino
Cancer Res June 1 1970 (30) (6) 1782-1788;
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Cancer Research Online ISSN: 1538-7445
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