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Articles

Cytogenetic Effects of Bleomycin Therapy in Man

Richard S. Bornstein, David A. Hungerford, Gail Haller, Paul F. Engstrom and John W. Yarbro
Richard S. Bornstein
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David A. Hungerford
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Gail Haller
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Paul F. Engstrom
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John W. Yarbro
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DOI:  Published December 1971
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Summary

Direct, air-dried preparations of metaphase chromosomes from bone marrow cells from four cancer patients were made prior to, during, and after treatment with the antitumor agent, bleomycin. An increase in the number of chromosomal aberrations was observed following administration of bleomycin; these persisted in two of the patients approximately 1 month after therapy. The aberrations consisted of hypochromatic regions, gaps, and breaks, all of which were of both the chromatid and isochromatid types; not present, however, were multiradials, dicentrics, and rings. Histopathological studies of the marrow showed no abnormalities. The disparity between cytogenetic and histopathological findings remains unexplained.

Footnotes

  • ↵1 This research was supported in part by USPHS Grants CA-11266, CA-05903, CA-12211, GM-17551, CA-06927, RR-05539, and CA-06551 and by an appropriation from the Commonwealth of Pennsylvania.

  • Received July 8, 1971.
  • Accepted August 18, 1971.
  • ©1971 American Association for Cancer Research.
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December 1971
Volume 31, Issue 12
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Cytogenetic Effects of Bleomycin Therapy in Man
Richard S. Bornstein, David A. Hungerford, Gail Haller, Paul F. Engstrom and John W. Yarbro
Cancer Res December 1 1971 (31) (12) 2004-2007;

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Cytogenetic Effects of Bleomycin Therapy in Man
Richard S. Bornstein, David A. Hungerford, Gail Haller, Paul F. Engstrom and John W. Yarbro
Cancer Res December 1 1971 (31) (12) 2004-2007;
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