Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

Comparison of the Mitochondrial Membrane Proteins in Rat Liver and Hepatomas

Lillie O. Chang, Carl A. Schnaitman and Harold P. Morris
Lillie O. Chang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carl A. Schnaitman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harold P. Morris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published February 1971
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

The mitochondrial membrane proteins isolated from normal rat liver, five hepatoma strains (H35, H35-tc1, H35-tc2, 3924A, and 9098), and tumor-bearing host liver have been compared by polyacrylamide gel electrophoresis. The mitochondrial membranes were isolated from gradient-purified mitochondria by extraction of soluble mitochondrial proteins with the detergent Lubrol WX, and lipid-free proteins were obtained by gel filtration of the membranes solubilized in acidified dimethylformamide. The major protein bands observed with membranes isolated from normal liver and liver from tumor-bearing (H35) rats were identical. A major protein band observed with membranes isolated from normal liver was missing or greatly reduced in membranes isolated from all of the hepatomas. Membranes from hepatoma H35 had a major protein band that was missing or present in very small amounts in membranes from normal liver. This additional band was also observed in lesser amounts in other hepatoma membranes. These changes in electrophoretic patterns suggest alteration of the inner mitochrondrial membrane proteins of hepatoma mitochondria.

Footnotes

  • ↵1 This investigation was supported in part by American Cancer Society Grant P-497, National Science Foundation Grant GB 8142, and USPHS Grant CA-10729.

  • Received April 30, 1970.
  • Accepted September 25, 1970.
  • ©1971 American Association for Cancer Research.
PreviousNext
Back to top
February 1971
Volume 31, Issue 2
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Comparison of the Mitochondrial Membrane Proteins in Rat Liver and Hepatomas
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Comparison of the Mitochondrial Membrane Proteins in Rat Liver and Hepatomas
Lillie O. Chang, Carl A. Schnaitman and Harold P. Morris
Cancer Res February 1 1971 (31) (2) 108-113;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Comparison of the Mitochondrial Membrane Proteins in Rat Liver and Hepatomas
Lillie O. Chang, Carl A. Schnaitman and Harold P. Morris
Cancer Res February 1 1971 (31) (2) 108-113;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • The Role of Chimeric Paired Box Transcription Factors in the Pathogenesis of Pediatric Rhabdomyosarcoma
  • The Effect of Chromosomal Translocations in Acute Leukemias: The LMO2 Paradigm in Transcription and Development
  • Laureate Citations
Show more Articles
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement