Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Articles

Release of Thymidine from X-irradiated Spleen in the Rabbit as Determined by a New Bioassay

Pierre A. Maurice
Pierre A. Maurice
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published December 1972
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

Plasma collected from the spleen of rabbits 2 to 4 hr after selective splenic irradiation decreased from 75 to 95% the uptake of 125I-labeled 5-iodo-2′-deoxyuridine by a suspension of bone marrow cells from untreated rabbits. The factor responsible for the decreased uptake was found to be dialyzable and, on paper chromatography in 4 different solvent systems, had the same RF values as did thymidine. Serial dilutions of this factor gave a dose-related response in the bone marrow suspensions that was identical to that obtained with thymidine, 0.01 to 0.25 µg/ml, confirming the chromatographic identification of the plasma factor as thymidine. The extent of thymidine release as measured by this sensitive method may be useful in evaluating early cell damage following X-irradiation.

Footnotes

  • ↵1 Supported by Research Grants CA-5834 and CA-12585 from the NIH, USPHS, and by Grants 3.114.69 and 3.386.70 from the Fonds National Suisse de la Recherche Scientifique.

  • Received June 12, 1972.
  • Accepted September 13, 1972.
  • ©1972 American Association for Cancer Research.
PreviousNext
Back to top
December 1972
Volume 32, Issue 12
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Release of Thymidine from X-irradiated Spleen in the Rabbit as Determined by a New Bioassay
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Release of Thymidine from X-irradiated Spleen in the Rabbit as Determined by a New Bioassay
Pierre A. Maurice
Cancer Res December 1 1972 (32) (12) 2799-2802;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Release of Thymidine from X-irradiated Spleen in the Rabbit as Determined by a New Bioassay
Pierre A. Maurice
Cancer Res December 1 1972 (32) (12) 2799-2802;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
  • Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice
  • The Prizes
Show more Articles
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement