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An in Vivo Evaluation of the Chemotherapeutic Potency of Phenylalanine Ammonia-Lyase

C. W. Abell, D. S. Hodgins and W. J. Stith
C. W. Abell
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D. S. Hodgins
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W. J. Stith
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DOI:  Published October 1973
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Summary

Phenylalanine ammonia-lyase from yeast was evaluated for its chemotherapeutic effectiveness against the murine L5178Y lymphoblastic leukemia maintained in C57BL/6 × DBA/2 F1 (BD2F1) mice. This enzyme, administered at concentrations of 300 units/kg, rapidly lowered plasma phenylalanine and tyrosine levels, inhibited tumor growth, and produced cures in 40% of the mice. Partially purified preparations of this enzyme, coupled with diets containing low levels of phenylalanine, significantly increased the average life-span of the mice and also produced cures. These results suggest that phenylalanine ammonia-lyase may be a valuable new chemotherapeutic agent for the treatment of some neoplasms.

Footnotes

  • ↵1 This study was supported in part by USPHS Research Grant CA-11732 from the National Cancer Institute.

  • ↵2 On sabbatical leave from the University of Oklahoma Health Sciences Center, Oklahoma City, Okla. 73190.

  • Received July 2, 1973.
  • Accepted August 7, 1973.
  • ©1973 American Association for Cancer Research.
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October 1973
Volume 33, Issue 10
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An in Vivo Evaluation of the Chemotherapeutic Potency of Phenylalanine Ammonia-Lyase
C. W. Abell, D. S. Hodgins and W. J. Stith
Cancer Res October 1 1973 (33) (10) 2529-2532;

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An in Vivo Evaluation of the Chemotherapeutic Potency of Phenylalanine Ammonia-Lyase
C. W. Abell, D. S. Hodgins and W. J. Stith
Cancer Res October 1 1973 (33) (10) 2529-2532;
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