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The Failure of Allopurinol to Enhance 6-Mercaptopurine Toxicity in Rabbits

R. I. Walker, W. L. Horvath, W. S. Rule, J. C. Herion and J. G. Palmer
R. I. Walker
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W. L. Horvath
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W. S. Rule
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J. C. Herion
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J. G. Palmer
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DOI:  Published April 1973
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Summary

We have evaluated the effect of allopurinol on the hematopoietic toxicity of 6-mercaptopurine in rabbits by studying the development of neutropenia in animals that received only 6-mercaptopurine and in those that received both drugs. The studies showed that, rather than demonstrating any potentiation of 6-mercaptopurine toxicity, allopurinol protected the animals, as evidenced by less weight loss, less depression of neutrophils, and lower mortality.

Footnotes

  • ↵1 Supported by NIH Grants CA07028, 1-K3CA9554, AI04925, and 5TO1-AMO5345 and by an Institutional Grant from the American Cancer Society.

  • ↵2 Trainee in Hematology.

  • ↵3 Predoctoral Fellow.

  • Received October 30, 1972.
  • Accepted January 18, 1973.
  • ©1973 American Association for Cancer Research.
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April 1973
Volume 33, Issue 4
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The Failure of Allopurinol to Enhance 6-Mercaptopurine Toxicity in Rabbits
R. I. Walker, W. L. Horvath, W. S. Rule, J. C. Herion and J. G. Palmer
Cancer Res April 1 1973 (33) (4) 755-758;

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The Failure of Allopurinol to Enhance 6-Mercaptopurine Toxicity in Rabbits
R. I. Walker, W. L. Horvath, W. S. Rule, J. C. Herion and J. G. Palmer
Cancer Res April 1 1973 (33) (4) 755-758;
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Cancer Research Online ISSN: 1538-7445
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