Summary
We have evaluated the effect of allopurinol on the hematopoietic toxicity of 6-mercaptopurine in rabbits by studying the development of neutropenia in animals that received only 6-mercaptopurine and in those that received both drugs. The studies showed that, rather than demonstrating any potentiation of 6-mercaptopurine toxicity, allopurinol protected the animals, as evidenced by less weight loss, less depression of neutrophils, and lower mortality.
Footnotes
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↵1 Supported by NIH Grants CA07028, 1-K3CA9554, AI04925, and 5TO1-AMO5345 and by an Institutional Grant from the American Cancer Society.
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↵2 Trainee in Hematology.
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↵3 Predoctoral Fellow.
- Received October 30, 1972.
- Accepted January 18, 1973.
- ©1973 American Association for Cancer Research.
April 1973
Volume 33, Issue 4
Volume 33, Issue 4
The Failure of Allopurinol to Enhance 6-Mercaptopurine Toxicity in Rabbits
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