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Serum Inhibition of in Vitro 67Ga Binding by L1210 Leukemic Cells

Richard A. Gams, John Webb and Jerry D. Glickson
Richard A. Gams
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John Webb
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Jerry D. Glickson
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DOI:  Published June 1975
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Summary

The influence of human serum on in vitro 67Ga uptake by L1210 leukemic lymphoblasts has been investigated. Both high- and low-molecular-weight serum components inhibit cellular uptake of the isotope. Inhibition by the high-molecular-weight serum fraction correlates closely with the extent of binding of the radionuclide. Although transferrin participates in high-molecular-weight inhibition, it accounts for 10% or less of the inhibitory and binding capacity. Similarly, various low-molecular-weight serum components, including citrate, phosphate, glutamate, and others, contribute to inhibition. This inhibition of 67Ga uptake by serum results from the presence of several, perhaps many, inhibitory components.

Footnotes

  • ↵1 This research was supported by NIH Grant CA-13148.

  • Received May 28, 1974.
  • Accepted February 14, 1975.
  • ©1975 American Association for Cancer Research.
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June 1975
Volume 35, Issue 6
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Serum Inhibition of in Vitro 67Ga Binding by L1210 Leukemic Cells
Richard A. Gams, John Webb and Jerry D. Glickson
Cancer Res June 1 1975 (35) (6) 1422-1426;

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Serum Inhibition of in Vitro 67Ga Binding by L1210 Leukemic Cells
Richard A. Gams, John Webb and Jerry D. Glickson
Cancer Res June 1 1975 (35) (6) 1422-1426;
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