Summary
The metabolism of both testosterone and dehydroepian-drosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin > 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin < 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5α-dihydrotestosterone and 5α-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C19 steroids by rat mammary adenocarcinomas.
Footnotes
-
↵1 This work was performed with a grant from the Cancer Research Campaign, Grant SP 1256.
- Received March 24, 1975.
- Accepted October 20, 1975.
- ©1976 American Association for Cancer Research.
February 1976
Volume 36, Issue 2 Part 1
Volume 36, Issue 2 Part 1
Hyperprolactinemia and Steroid Metabolism by Rat Mammary Adenocarcinomas
Permalink:
Jump to section
Advertisement