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Hyperprolactinemia and Steroid Metabolism by Rat Mammary Adenocarcinomas

William R. Miller
William R. Miller
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DOI:  Published February 1976
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Summary

The metabolism of both testosterone and dehydroepian-drosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin > 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin < 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5α-dihydrotestosterone and 5α-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C19 steroids by rat mammary adenocarcinomas.

Footnotes

  • ↵1 This work was performed with a grant from the Cancer Research Campaign, Grant SP 1256.

  • Received March 24, 1975.
  • Accepted October 20, 1975.
  • ©1976 American Association for Cancer Research.
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February 1976
Volume 36, Issue 2 Part 1
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Hyperprolactinemia and Steroid Metabolism by Rat Mammary Adenocarcinomas
William R. Miller
Cancer Res February 1 1976 (36) (2 Part 1) 336-338;

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Hyperprolactinemia and Steroid Metabolism by Rat Mammary Adenocarcinomas
William R. Miller
Cancer Res February 1 1976 (36) (2 Part 1) 336-338;
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
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