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Establishment of a Human Carcinoembryonic Antigen-producing Colon Adenocarcinoma Cell Line

B. Drewinko, M. M. Romsdahl, L. Y. Yang, M. J. Ahearn and J. M. Trujillo
B. Drewinko
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M. M. Romsdahl
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L. Y. Yang
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M. J. Ahearn
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J. M. Trujillo
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DOI:  Published February 1976
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Summary

A human carcinoembryonic antigen-producing colon carcinoma cell line has been established. The cells form acinar structures and signet ring cells. The lumen of the acini presents microvilli and a glycocalyx. Neighboring cells show desmosomes and terminal bars. The cells present an aneuploid karyotype with a modal number of 49. No marker chromosomes are found, although a significant proportion of cells show an altered A2 chromosome and an extra B. Exponentially growing cultures produce 54 ng of carcinoembryonic antigen/106 cells. Kinetic parameters are as follows: doubling time, 37 hr; mitotic index, 0.8%; labeling index, 31%; generation time, 30 hr; G1 phase, 7 hr; S phase, 18 hr; G2 phase, 5 hr; growth fraction 90%. This cell line, designated line LoVo, represents an in vitro model for human colon carcinoma.

Footnotes

  • ↵1 This investigation was supported by USPHS Grant CA-16763 from the National Cancer Institute through the National Large Bowel Cancer Project.

  • Received June 30, 1975.
  • Accepted October 20, 1975.
  • ©1976 American Association for Cancer Research.
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February 1976
Volume 36, Issue 2 Part 1
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Establishment of a Human Carcinoembryonic Antigen-producing Colon Adenocarcinoma Cell Line
B. Drewinko, M. M. Romsdahl, L. Y. Yang, M. J. Ahearn and J. M. Trujillo
Cancer Res February 1 1976 (36) (2 Part 1) 467-475;

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Establishment of a Human Carcinoembryonic Antigen-producing Colon Adenocarcinoma Cell Line
B. Drewinko, M. M. Romsdahl, L. Y. Yang, M. J. Ahearn and J. M. Trujillo
Cancer Res February 1 1976 (36) (2 Part 1) 467-475;
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