Abstract
Mice were given injections of C-type particles extracted from the ascitic fluid of plasmacytoma-bearing mice. These particles, extracted from MOPC-315 tumor-bearing mice and injected into BALB/c mice, protected them against challenge with MOPC-315 tumor cells. The protection was dependent upon tumor cell dose; 66% survival was observed with a lethal dose of tumor cells. No protection was observed against challenge with another plasmacytoma (S-13). Attempts to protect mice against S-13 plasmacytoma by immunizing them with C-type particles originating from S-13 tumor-bearing mice were unsuccessful.
Footnotes
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↵1 Supported by a Campus Research Board grant of the Graduate College of the University of Illinois at the Medical Center and by National Cancer Institute Grant CA-18241.
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↵2 To whom requests for reprints should be addressed.
- Received August 19, 1977.
- Accepted November 4, 1977.
- ©1978 American Association for Cancer Research.
Volume 38, Issue 1
