Abstract
Administration of ovine growth hormone to young C3Hf mice inhibited Gross passage A virus-induced leukemogenesis as manifested by a delayed onset and a lower incidence of thymus leukemia. These results can be interpreted that growth hormone inhibited thymus-dependent leukemogenesis perhaps through thymotrophic influences which prevented or delayed the thymus involution believed to be essential for leukemia change. In female but not in male Gross passage A virus-infected mice, development of a thymus-independent leukemia appeared to be promoted by growth hormone.
Footnotes
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↵1 This work was supported by Grant DRG-1224 from the Damon Runyon-Walter Winchell Cancer Foundation and by NIH Grant Al12507.
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↵2 To whom requests for reprints should be addressed.
- Received June 27, 1978.
- Accepted November 3, 1978.
- ©1979 American Association for Cancer Research.
February 1979
Volume 39, Issue 2 Part 1
Volume 39, Issue 2 Part 1
Inhibitory Effect of Growth Hormone on Gross Passage A Virus-induced Thymus Leukemia in C3Hf Mice
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