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Inhibitory Effect of Growth Hormone on Gross Passage A Virus-induced Thymus Leukemia in C3Hf Mice

René J. Duquesnoy and Grete M. Pedersen
René J. Duquesnoy
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Grete M. Pedersen
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DOI:  Published February 1979
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Abstract

Administration of ovine growth hormone to young C3Hf mice inhibited Gross passage A virus-induced leukemogenesis as manifested by a delayed onset and a lower incidence of thymus leukemia. These results can be interpreted that growth hormone inhibited thymus-dependent leukemogenesis perhaps through thymotrophic influences which prevented or delayed the thymus involution believed to be essential for leukemia change. In female but not in male Gross passage A virus-infected mice, development of a thymus-independent leukemia appeared to be promoted by growth hormone.

Footnotes

  • ↵1 This work was supported by Grant DRG-1224 from the Damon Runyon-Walter Winchell Cancer Foundation and by NIH Grant Al12507.

  • ↵2 To whom requests for reprints should be addressed.

  • Received June 27, 1978.
  • Accepted November 3, 1978.
  • ©1979 American Association for Cancer Research.
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February 1979
Volume 39, Issue 2 Part 1
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Inhibitory Effect of Growth Hormone on Gross Passage A Virus-induced Thymus Leukemia in C3Hf Mice
René J. Duquesnoy and Grete M. Pedersen
Cancer Res February 1 1979 (39) (2 Part 1) 415-418;

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Inhibitory Effect of Growth Hormone on Gross Passage A Virus-induced Thymus Leukemia in C3Hf Mice
René J. Duquesnoy and Grete M. Pedersen
Cancer Res February 1 1979 (39) (2 Part 1) 415-418;
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Cancer Research Online ISSN: 1538-7445
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