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Articles

Derivation of Human T-Cell Leukemias

Ellis L. Reinherz and Stuart F. Schlossman
Ellis L. Reinherz
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Stuart F. Schlossman
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DOI:  Published November 1981
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Abstract

Cell surface antigenic changes occur during the stages of T-cell ontogeny in several animal model systems. In the present study, multiple monoclonal antibodies were developed to human thymocyte and T-cell surface differentiation antigens as a means of probing T-cell ontogeny in humans. It was shown that three distinct stages of human intrathymic differentiation exist and that the mature inducer (T4+) and suppressor (T5+/TH2+) T-cell subsets arise at specific points during these maturation events. Moreover, T-cell leukemias can now be related to the three stages of the thymic compartment or, alternatively, the more differentiated peripheral T-cell compartment.

Footnotes

  • ↵2 To whom requests for reprints should be addressed, at Division of Tumor Immunology, Sidney Farber Cancer Institute, 44 Binney Street, Boston, Mass. 02115.

    • ©1981 American Association for Cancer Research.
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    November 1981
    Volume 41, Issue 11 Part 2
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    Derivation of Human T-Cell Leukemias
    Ellis L. Reinherz and Stuart F. Schlossman
    Cancer Res November 1 1981 (41) (11 Part 2) 4767-4770;

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    Derivation of Human T-Cell Leukemias
    Ellis L. Reinherz and Stuart F. Schlossman
    Cancer Res November 1 1981 (41) (11 Part 2) 4767-4770;
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