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Clinical Investigations

Synthesis of a Viral Protein with Molecular Weight of 30,000 (p30) by Leukemic Cells and Antibodies Cross-Reacting with Simian Sarcoma Virus p30 in Serum of a Chronic Myeloid Leukemia Patient

Jos P. A. Derks, Lilian Hofmans, Hans W. Bruning and Jon J. v. Rood
Jos P. A. Derks
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Lilian Hofmans
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Hans W. Bruning
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Jon J. v. Rood
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DOI:  Published February 1982
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Abstract

We studied a patient with a Philadelphia chromosome-positive chronic myeloid leukemia, who died in relapse after multiple transfusions and grafting with bone marrow from his monozygotic twin brother (referred to as “donor” in this paper). We present data indicating that this patient may have had a retrovirus infection and that this virus is related to the group of exogenous primate type C retroviruses.

Antibodies to simian sarcoma virus (SSV) M.W. 30,000 protein (p30) but not endogenous feline virus RD-114 could be found in patient but not donor serum. Patient but not donor cells were able to actively synthesize a p30 protein that could be precipitated with patient serum and rabbit anti-SSV p30 but not with donor serum or rabbit anti-RD-114 p30. Patient p30 resembles SSV p30 but not RD-114 p30 in peptide mapping by limited proteolysis and subsequent slab gel electrophoresis. Patient but not donor cells were able to actively synthesize a M.W. 78,000 protein that could be precipitated with goat anti-SSV. An enzyme with properties of reverse transcriptase was increased 30-fold in patient cells when compared with donor and other control cells.

Related to the presence of widespread infectious agents may be the finding that, in the course of the patient's disease, donor serum showed increasing amounts of possibly immunoregulatory (Cancer Research, submitted for publication) antibodies, reactive with autologous and, more effectively, with patientderived cell membrane M.W. 80,000 protein (a possible idiotypic receptor structure) and M.W. 94,000 protein (a T-cell alloantigen).

Footnotes

  • ↵1 This study was supported by the Queen Wilhelmina Foundation, the Dutch Cancer Research Fund (Project LUKC-I-76.33).

  • ↵2 This article is one of a series of two. Paper 2, submitted to Cancer Research, is entitled, “Molecular Characterization of the TCA-1 Alloantigen on T-Cells of a Leukemic Patient with Serum from a Monozygotic Twin Brother.”

  • 3 To whom requests for reprints should be addressed.

  • Received September 9, 1980.
  • Accepted October 23, 1981.
  • ©1982 American Association for Cancer Research.
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February 1982
Volume 42, Issue 2
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Synthesis of a Viral Protein with Molecular Weight of 30,000 (p30) by Leukemic Cells and Antibodies Cross-Reacting with Simian Sarcoma Virus p30 in Serum of a Chronic Myeloid Leukemia Patient
Jos P. A. Derks, Lilian Hofmans, Hans W. Bruning and Jon J. v. Rood
Cancer Res February 1 1982 (42) (2) 681-686;

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Synthesis of a Viral Protein with Molecular Weight of 30,000 (p30) by Leukemic Cells and Antibodies Cross-Reacting with Simian Sarcoma Virus p30 in Serum of a Chronic Myeloid Leukemia Patient
Jos P. A. Derks, Lilian Hofmans, Hans W. Bruning and Jon J. v. Rood
Cancer Res February 1 1982 (42) (2) 681-686;
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