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Basic Sciences

Prevention of Interferon-induced Augmentation of Cellular Antitumor Effector Mechanisms by Phorbol Esters

R. Keller, M. Aguet, M. Tovey and L. Stitz
R. Keller
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M. Aguet
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M. Tovey
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L. Stitz
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DOI:  Published April 1982
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Abstract

Both natural killer cell- and macrophage-mediated spontaneous in vitro cytotoxicity for tumor targets is rapidly and strongly augmented by interferon. Macrophage-activating lymphokines considerably enhance macrophage-tumoricidal activity but did not affect natural killer cell-type cytotoxicity. Augmentation of cytolytic capacity by interferon and by macrophage-activating lymphokines is prevented by the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate. However, the classical antiviral activity and the specific binding of interferon to cell surface receptors remains unaffected by 12-O-tetradecanoylphorbol-13-acetate.

Footnotes

  • ↵1 This work was supported by the Swiss National Science Foundation (Grants 3.173.77 and 3.609.80) and the Direction des Etudes Recherche et Technique (Contracts 78-34-210/80-34-522).

  • ↵2 Supported by the Canton of Zurich. To whom requests for reprints should be addressed.

  • ↵3 Supported by the Association pour le Développement de la Recherche sur le Cancer à Villejuif.

  • ↵4 Recipient of Fellowship Sti 71/1-1 from Deutsche Forschungsgemeinschaft.

  • Received October 13, 1981.
  • Accepted January 7, 1982.
  • ©1982 American Association for Cancer Research.
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April 1982
Volume 42, Issue 4
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Prevention of Interferon-induced Augmentation of Cellular Antitumor Effector Mechanisms by Phorbol Esters
R. Keller, M. Aguet, M. Tovey and L. Stitz
Cancer Res April 1 1982 (42) (4) 1468-1472;

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Prevention of Interferon-induced Augmentation of Cellular Antitumor Effector Mechanisms by Phorbol Esters
R. Keller, M. Aguet, M. Tovey and L. Stitz
Cancer Res April 1 1982 (42) (4) 1468-1472;
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