Abstract
The effect of complete Freund's adjuvant (CFA), which is one of the strong immunoadjuvants, on the induction of either cytotoxic or suppressor T-cells against syngeneic tumors was investigated by an in vitro assay system. CFA did not show the apparent augmenting activity in the induction of cytotoxic T-cells against syngeneic tumors when it was administered i.p. to mice receiving s.c. inoculations of mitomycin C-treated tumor cells. The treated animals failed to develop stronger resistance against the second inoculum of the same viable tumor cells. Furthermore, CFA had an effect on the induction of suppressor T-cells in tumor-bearing hosts in which suppressor T-cells had been readily activated. Suppressor T-cells developed in syngeneic tumor-bearing mice treated with CFA was tumor specific. Tumor growth was enhanced when CFA was administered to mice given s.c. inoculations of the homologous tumor.
Footnotes
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↵1 This study was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
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↵2 To whom requests for reprints should be addressed.
- Received December 28, 1981.
- Accepted May 6, 1982.
- ©1982 American Association for Cancer Research.
Volume 42, Issue 8
