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Basic Sciences

Correlation of Malignancy with the Intracellular Na+:K+ Ratio in Human Thyroid Tumors

Imre Zs.-Nagy, György Lustyik, Géza Lukács, Valéria Zs.-Nagy and György Balázs
Imre Zs.-Nagy
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György Lustyik
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Géza Lukács
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Valéria Zs.-Nagy
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György Balázs
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DOI:  Published November 1983
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Abstract

Energy-dispersive X-ray microanalysis was applied on human intraoperative biopsy materials of different thyroid tumors. To ensure suitability of these tissue pieces for quantitative microanalysis in freeze-fractured, freeze-dried bulk specimens, sampling was carried out with strictly defined criteria. Benign adenomas and differentiated and anaplastic carcinomas were selected for the studies on the basis of pathohistological investigations of the same specimen. The results of the tumor cells were compared to those obtained in apparently normal human epithelial cells. The number of normal cells analyzed was 349, whereas in the tumors 408, 423, and 891 cells were measured in the benign, differentiated, and anaplastic groups, respectively. Intracellular monovalent contents were calculated as percentage of cell dry mass; then, Na+:K+ molar ratios were calculated for each cell individually. Due mostly to the increase of Na+ content, the distribution histograms of the Na+:K+ molar ratio show an increase in the number of cells with a higher Na+:K+ ratio with increasing malignancy of the tumors studied. The differences proved to be statistically highly significant by the x2 test. Thus, in human thyroid, increasing malignancy is associated with increasing intracellular Na+:K+ ratio.

The results give further support to the theory of C. D. Cone (J. Theor. Biol., 30: 151–181, 1971) according to which the sustained depolarization of the cell membrane results in an increased rate of cell division.

Footnotes

  • ↵1 Supported in part by Grants 144/79-II and 360/82/3.1 of the Hungarian Academy of Sciences.

  • ↵2 To whom requests for reprints should be addressed, at VILEG Hungarian Section, University Medical School, H-4012 Debrecen, Hungary.

  • Received March 4, 1982.
  • Accepted July 27, 1983.
  • ©1983 American Association for Cancer Research.
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November 1983
Volume 43, Issue 11
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Correlation of Malignancy with the Intracellular Na+:K+ Ratio in Human Thyroid Tumors
Imre Zs.-Nagy, György Lustyik, Géza Lukács, Valéria Zs.-Nagy and György Balázs
Cancer Res November 1 1983 (43) (11) 5395-5402;

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Correlation of Malignancy with the Intracellular Na+:K+ Ratio in Human Thyroid Tumors
Imre Zs.-Nagy, György Lustyik, Géza Lukács, Valéria Zs.-Nagy and György Balázs
Cancer Res November 1 1983 (43) (11) 5395-5402;
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