Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Basic Sciences

Inhibition of N-Nitrosodiethylamine-induced Respiratory Tract Carcinogenesis by Piperonylbutoxide in Hamsters

Hildegard M. Schuller and James B. McMahon
Hildegard M. Schuller
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James B. McMahon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published June 1985
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The influence of pretreatment with piperonylbutoxide (PIP) on the biological effects of N-nitrosodiethylamine (DEN) in vivo in Syrian golden hamsters was investigated. PIP pretreatment significantly reduced covalent binding of N-[ethyl-1-14C]DEN to tissue macromolecules in trachea, lung, and liver, while it did not change the tissue distribution of the parent compound. In a chronic experiment, hamsters treated with PIP before each DEN injection did not develop any tumors or precancerous changes in the lungs, while 60% of the animals given DEN alone developed lung tumors with the morphology of Clara cells and endocrine cells. Tumor incidence in the trachea was also significantly reduced by PIP, but to a lesser extent than in the lungs.

Footnotes

  • ↵1 To whom requests for reprints should be addressed, at Laboratory of Experimental Therapeutics and Metabolism, Division of Cancer Treatment, National Cancer Institute, Bldg. 37, Room 5C11, Bethesda, MD 20205.

  • Received July 24, 1984.
  • Revision received October 31, 1984.
  • Revision received January 25, 1985.
  • Accepted March 8, 1985.
  • ©1985 American Association for Cancer Research.
PreviousNext
Back to top
June 1985
Volume 45, Issue 6
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Inhibition of N-Nitrosodiethylamine-induced Respiratory Tract Carcinogenesis by Piperonylbutoxide in Hamsters
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Inhibition of N-Nitrosodiethylamine-induced Respiratory Tract Carcinogenesis by Piperonylbutoxide in Hamsters
Hildegard M. Schuller and James B. McMahon
Cancer Res June 1 1985 (45) (6) 2807-2812;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Inhibition of N-Nitrosodiethylamine-induced Respiratory Tract Carcinogenesis by Piperonylbutoxide in Hamsters
Hildegard M. Schuller and James B. McMahon
Cancer Res June 1 1985 (45) (6) 2807-2812;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Basic Sciences

  • Glucocorticoid Insensitivity of P1798 Lymphoma Cells Is Associated with Production of a Factor That Attenuates the Lytic Response
  • Forestomach and Kidney Carcinogenicity of Caffeic Acid in F344 Rats and C57BL/6N × C3H/HeN F1 Mice
  • Immunohistochemical and Pharmacokinetic Characterization of Site-specific Immunoconjugate 15A8-Glycyl-tyrosyl-(N-ε-diethylenetriamine Pentaacetic Acid)-lysine Derived from Anti-Breast Carcinoma Monoclonal Antibody 15A8
Show more Basic Sciences

Articles

  • Glucocorticoid Insensitivity of P1798 Lymphoma Cells Is Associated with Production of a Factor That Attenuates the Lytic Response
  • Forestomach and Kidney Carcinogenicity of Caffeic Acid in F344 Rats and C57BL/6N × C3H/HeN F1 Mice
  • Immunohistochemical and Pharmacokinetic Characterization of Site-specific Immunoconjugate 15A8-Glycyl-tyrosyl-(N-ε-diethylenetriamine Pentaacetic Acid)-lysine Derived from Anti-Breast Carcinoma Monoclonal Antibody 15A8
Show more Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2019 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement