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Epidemiology and General Clinical Perspectives

Unique Pattern of HTLV-III (AIDS-related) Antigen Recognition by Sera from African Children in Uganda (1972)

Carl Saxinger, Paul H. Levine, Andy Dean, Gunhild Lange-Wantzin and Robert Gallo
Carl Saxinger
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Paul H. Levine
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Andy Dean
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Gunhild Lange-Wantzin
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Robert Gallo
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DOI:  Published September 1985
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Abstract

Of 75 sera collected in the West Nile district of Uganda over a 1-year period between 1972 and 1973, 50 (66%) had antibody reactivity to human T-cell lymphotropic virus subgroup III (HTLV-III) at low titer levels. Sera were initially screened by HTLV-III enzyme linked immunosorbent assay and sera with values less than normal mean + 2 SD were removed from testing. The remaining sera were tested for positivity by an amplified Western blotting procedure which incorporated a three-layer immunoper-oxidase procedure. Immunoglobulin reactive with HTLV-III Mr 24,000, 41,000, and 76,000 proteins were present in nearly all positive sera. The antibody status of this group was unlike any normal or acquired immunodeficiency syndrome-risk group previously tested. The high prevalence and relatively low titers suggest the detection as early as 1972 of a relative or predecessor of HTLV-III or of HTLV-III itself but existing in a population acclimated to its presence. It further suggests a likely African origin of HTLV-III.

Footnotes

  • ↵2 To whom requests for reprints should be addressed.

    • ©1985 American Association for Cancer Research.
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    September 1985
    Volume 45, Issue 9 Supplement
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    Unique Pattern of HTLV-III (AIDS-related) Antigen Recognition by Sera from African Children in Uganda (1972)
    Carl Saxinger, Paul H. Levine, Andy Dean, Gunhild Lange-Wantzin and Robert Gallo
    Cancer Res September 1 1985 (45) (9 Supplement) 4624s-4626s;

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    Unique Pattern of HTLV-III (AIDS-related) Antigen Recognition by Sera from African Children in Uganda (1972)
    Carl Saxinger, Paul H. Levine, Andy Dean, Gunhild Lange-Wantzin and Robert Gallo
    Cancer Res September 1 1985 (45) (9 Supplement) 4624s-4626s;
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