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Clinical and Epidemiological Investigations

Long-Term Adjuvant Therapy with Tamoxifen: Effects on Sex Hormone Binding Globulin and Antithrombin III

V. Craig Jordan, Nancy F. Fritz and Douglass C. Tormey
V. Craig Jordan
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Nancy F. Fritz
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Douglass C. Tormey
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DOI:  Published August 1987
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Abstract

Plasma levels of luteinizing hormone, sex hormone binding globulin, and antithrombin III were measured in pre- and postmenopausal breast cancer patients receiving adjuvant combination chemotherapy or combination chemotherapy and long-term tamoxifen therapy. The aim was to determine the estrogen-like effects of tamoxifen. The premenopausal patients had received tamoxifen for between 434 and 2592 days and postmenopausal patients between 91 and 1560 days. Tamoxifen caused a consistent rise in sex hormone binding globulin in premenopausal (P < 0.03) and postmenopausal (P < 0.01) patients compared to chemotherapy controls. Luteinizing hormone levels were only significantly lowered (P < 0.008) in premenopausal patients compared to chemotherapy controls. Antithrombin III levels were significantly depressed (P < 0.001) in postmenopausal patients compared with chemotherapy controls. However, none of the patients had a value that was depressed by more than 30% of the laboratory control (the level of clinical significance). The mean for the group was 90% ± 4 (mean ± SD, N = 11).

The estrogen-like rise in sex hormone binding globulin produced by adjuvant tamoxifen therapy could be advantageous for maintaining the antiestrogenic action of the drug. A decrease in antithrombin III occurred but was not within a range of clinical concern. We recommend, however, that patients with a history of thromboembolic disorders should be monitored carefully if placed on tamoxifen therapy.

Footnotes

  • ↵1 Supported by NIH Grants P30-CA-14520 and P01-CA-20432.

  • ↵2 To whom requests for reprints should be addressed, at Department of Human Oncology, University of Wisconsin Clinical Cancer Center, 600 Highland Avenue, Madison, WI 53792.

  • Received February 24, 1987.
  • Revision received May 21, 1987.
  • Accepted May 27, 1987.
  • ©1987 American Association for Cancer Research.
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August 1987
Volume 47, Issue 16
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Long-Term Adjuvant Therapy with Tamoxifen: Effects on Sex Hormone Binding Globulin and Antithrombin III
V. Craig Jordan, Nancy F. Fritz and Douglass C. Tormey
Cancer Res August 15 1987 (47) (16) 4517-4519;

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Long-Term Adjuvant Therapy with Tamoxifen: Effects on Sex Hormone Binding Globulin and Antithrombin III
V. Craig Jordan, Nancy F. Fritz and Douglass C. Tormey
Cancer Res August 15 1987 (47) (16) 4517-4519;
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