Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Basic Sciences

Regression of Simple Hyperplasia and Papillomas and Persistence of Basal Cell Hyperplasia in the Forestomach of F344 Rats Treated with Butylated Hydroxyanisole

Tsuneo Masui, Makoto Asamoto, Masao Hirose, Shoji Fukushima and Nobuyuki Ito
Tsuneo Masui
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Makoto Asamoto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masao Hirose
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shoji Fukushima
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nobuyuki Ito
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published October 1987
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The reversibility of forestomach lesions induced in rats by butylated hydroxyanisole (BHA) was examined. F344 rats were given a 2% BHA diet for 24, 48, or 72 wk followed by a basal diet for the remainder of the 96-wk experiment. Two other groups of rats were given a 2% BHA diet or basal diet alone for 96 wk. The forestomach lesions at wk 24, 48, 72, or 96 were compared histopathologically. The results showed that exophytic epithelial proliferation (simple hyperplasia or papilloma) induced by BHA was reversible, while endophytic proliferation of basal cells (basal cell hyperplasia) persisted after withdrawal of BHA administration. This suggests that simple hyperplasia and papilloma of the forestomach induced by BHA are not autonomous and need continuous feeding of BHA to develop further.

Footnotes

  • ↵1 Supported in part by Grants-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture and from the Ministry of Health and Welfare and by a Grant-in-Aid from the Ministry of Health and Welfare for Comprehensive 10-Year Strategy for Cancer Control, Japan.

  • Received August 25, 1986.
  • Revision received June 19, 1987.
  • Accepted June 24, 1987.
  • ©1987 American Association for Cancer Research.
PreviousNext
Back to top
October 1987
Volume 47, Issue 19
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Regression of Simple Hyperplasia and Papillomas and Persistence of Basal Cell Hyperplasia in the Forestomach of F344 Rats Treated with Butylated Hydroxyanisole
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Regression of Simple Hyperplasia and Papillomas and Persistence of Basal Cell Hyperplasia in the Forestomach of F344 Rats Treated with Butylated Hydroxyanisole
Tsuneo Masui, Makoto Asamoto, Masao Hirose, Shoji Fukushima and Nobuyuki Ito
Cancer Res October 1 1987 (47) (19) 5171-5174;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Regression of Simple Hyperplasia and Papillomas and Persistence of Basal Cell Hyperplasia in the Forestomach of F344 Rats Treated with Butylated Hydroxyanisole
Tsuneo Masui, Makoto Asamoto, Masao Hirose, Shoji Fukushima and Nobuyuki Ito
Cancer Res October 1 1987 (47) (19) 5171-5174;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Basic Sciences

  • Differential Expression of Transforming Growth Factor-β1 Gene in 3LL Metastatic Variants
  • Extracellular Matrix and the Patterns of Differentiation of Human Endometrial Carcinomas in Vitro and in Vivo
  • O6-Methylguanine Is a Critical Determinant of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Tumorigenesis in A/J Mouse Lung
Show more 3

Carcinogenesis

  • Abstract LB-094: Regorafenib and sildenafil interact to kill tumor cells
  • Abstract LB-089: Defining windows of susceptibility for low-dose exposure to endocrine disruptors in rat mammary development by microRNA profiling
  • Abstract LB-093: Activation of the FGFR1 signaling pathway by the epstein-barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells
Show more 3

Articles

  • Abstract LB-094: Regorafenib and sildenafil interact to kill tumor cells
  • Abstract LB-089: Defining windows of susceptibility for low-dose exposure to endocrine disruptors in rat mammary development by microRNA profiling
  • Abstract LB-093: Activation of the FGFR1 signaling pathway by the epstein-barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells
Show more 3
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement