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Basic Sciences

Reduced DNA Damage Induced in Human Melanoma Cells by Dacarbazine in the Presence of Deoxyribonucleosides

Ulf Lönn, Sigrid Lönn, Urban Nylen and Gerard Winblad
Ulf Lönn
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Sigrid Lönn
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Urban Nylen
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Gerard Winblad
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DOI:  Published June 1989
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Abstract

Decarbazine induces DNA lesions in replicating DNA. We show here that deoxyribonucleosides, with the exception of thymidine, in doses of 250 µm or higher, prevent dacarbazine-induced DNA lesions. The DNA lesions that appear in the presence of thymidine can be prevented by aphidicolin, an inhibitor of DNA synthesis. Cytotoxicity analyses confirm that the combination thymidine-dacarbazine prevents cell outgrowth only partially, while other deoxyribonucleosides completely abolish the dacarbazine effect.

Footnotes

  • ↵1 This work was supported by grants from the Swedish Cancer Society and Karolinska Institutet.

  • ↵2 To whom requests for reprints should be addressed, at Radiumhemmet, Karolinska Hospital, PO Box 60500, S-104 01 Stockholm, Sweden.

  • Received September 27, 1988.
  • Revision received February 15, 1989.
  • Accepted February 16, 1989.
  • ©1989 American Association for Cancer Research.
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June 1989
Volume 49, Issue 11
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Reduced DNA Damage Induced in Human Melanoma Cells by Dacarbazine in the Presence of Deoxyribonucleosides
Ulf Lönn, Sigrid Lönn, Urban Nylen and Gerard Winblad
Cancer Res June 1 1989 (49) (11) 2921-2924;

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Reduced DNA Damage Induced in Human Melanoma Cells by Dacarbazine in the Presence of Deoxyribonucleosides
Ulf Lönn, Sigrid Lönn, Urban Nylen and Gerard Winblad
Cancer Res June 1 1989 (49) (11) 2921-2924;
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