Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Perspectives in Cancer Research

Changes in Plasma Lipid and Lipoprotein Cholesterol and Weight prior to the Diagnosis of Cancer

Stephen B. Kritchevsky, Timothy C. Wilcosky, Dexter L. Morris, Kinh N. Truong and Herman A. Tyroler
Stephen B. Kritchevsky
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timothy C. Wilcosky
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dexter L. Morris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kinh N. Truong
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Herman A. Tyroler
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published June 1991
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Changes in lipoprotein cholesterol, total plasma cholesterol, and weight prior to the diagnosis of cancer were examined in 103 men who developed cancer in a cohort of 3805 type IIa hyperlipidemic men aged 35–59 enrolled in the Lipid Research Clinics Coronary Primary Prevention Trial. Study measurements were made bimonthly. After adjusting for the effects of the trial intervention and other determinants of lipid levels, the cholesterol levels of the cases diagnosed with nonlocalized cancer dropped below the expected level approaching diagnosis when compared to the entire study population. The decrease averaged 9.3 mg/dl and began about 2 years prior to diagnosis. Weight levels dropped an average of 1.2 kg over the same period. Weight and cholesterol were significantly lower than expected within 8 months of diagnosis (P < 0.05). No decrease was seen for those diagnosed with localized malignancies. Patterns for low-density lipoprotein cholesterol reflected those of total cholesterol. There was no clear relationship between cancer diagnosis and patterns of change for triglycerides and high-density lipoprotein cholesterol. In the future, investigations of any relationship between a host physiological state and cancer occurrence should account for the metabolic effects of preclinical disease demonstrated here. To protect against spurious conclusions, incident cases occurring within 2 years of measurement should be analyzed separately. In studies of cancer mortality, deaths occurring within 3.5 years of the base-line measurement should be analyzed separately.

Footnotes

  • ↵1 This work was supported, in part, by National Cancer Institute Grant RO3-CA47076-01.

  • ↵2 To whom requests for reprints should be addressed, at Department of Biostatistics and Epidemiology, University of Tennessee, Memphis, Lamar Alexander Building, 877 Madison Avenue, Memphis, TN 38163.

  • Received January 18, 1991.
  • Accepted April 3, 1991.
  • ©1991 American Association for Cancer Research.
PreviousNext
Back to top
June 1991
Volume 51, Issue 12
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Changes in Plasma Lipid and Lipoprotein Cholesterol and Weight prior to the Diagnosis of Cancer
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Changes in Plasma Lipid and Lipoprotein Cholesterol and Weight prior to the Diagnosis of Cancer
Stephen B. Kritchevsky, Timothy C. Wilcosky, Dexter L. Morris, Kinh N. Truong and Herman A. Tyroler
Cancer Res June 15 1991 (51) (12) 3198-3203;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Changes in Plasma Lipid and Lipoprotein Cholesterol and Weight prior to the Diagnosis of Cancer
Stephen B. Kritchevsky, Timothy C. Wilcosky, Dexter L. Morris, Kinh N. Truong and Herman A. Tyroler
Cancer Res June 15 1991 (51) (12) 3198-3203;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Perspectives in Cancer Research

  • Lessons from Applied Ecology: Cancer Control Using an Evolutionary Double Bind
  • Behavioral Oncology and the War on Cancer: Partnering with Biomedicine
  • Did Experimental Biology Die? Lessons from 30 Years of p53 Research
Show more 3

Articles

  • Membership of Advisory Council
  • Introduction of H. Robert Horvitz
  • Mammary Gland Development, Reproductive History, and Breast Cancer Risk
Show more 3
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement