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Expression of the GLUT1 Glucose Transporter Increases Thymidine Uptake in Chinese Hamster Ovary Cells at Low Glucose Concentrations

Tomoichiro Asano, Yoshikazu Shibasaki, Jiann-Liang Lin, Katsunori Tsukuda, Hideki Katagiri, Hisamitsu Ishihara, Yoshio Yazaki and Yoshitomo Oka
Tomoichiro Asano
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Yoshikazu Shibasaki
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Jiann-Liang Lin
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Katsunori Tsukuda
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Hideki Katagiri
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Hisamitsu Ishihara
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Yoshio Yazaki
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Yoshitomo Oka
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DOI:  Published August 1991
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Abstract

An increase in expression of the GLUT1 glucose transporter gene has been observed to be associated with an increase in glucose transport activity upon oncogenic transformation of the cells. Increased expression of this glucose transporter isoform has been also observed in fetal tissues. To investigate the consequences of this phenomenon on cellular metabolism and cell growth, an expression vector containing the GLUT1 glucose transporter complementary DNA was transfected into Chinese hamster ovary cells. Overexpression of this glucose transporter isoform resulted in an increase in not only glucose uptake and utilization but also thymidine uptake when cells were exposed to glucose-deficient conditions. This increase in glucose metabolism and DNA synthesis may play an important role on the growth and/or survival of cancer cells and fetal tissues.

Footnotes

  • ↵1 This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.

  • Received February 27, 1991.
  • Accepted June 6, 1991.
  • ©1991 American Association for Cancer Research.
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August 1991
Volume 51, Issue 16
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Expression of the GLUT1 Glucose Transporter Increases Thymidine Uptake in Chinese Hamster Ovary Cells at Low Glucose Concentrations
Tomoichiro Asano, Yoshikazu Shibasaki, Jiann-Liang Lin, Katsunori Tsukuda, Hideki Katagiri, Hisamitsu Ishihara, Yoshio Yazaki and Yoshitomo Oka
Cancer Res August 15 1991 (51) (16) 4450-4454;

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Expression of the GLUT1 Glucose Transporter Increases Thymidine Uptake in Chinese Hamster Ovary Cells at Low Glucose Concentrations
Tomoichiro Asano, Yoshikazu Shibasaki, Jiann-Liang Lin, Katsunori Tsukuda, Hideki Katagiri, Hisamitsu Ishihara, Yoshio Yazaki and Yoshitomo Oka
Cancer Res August 15 1991 (51) (16) 4450-4454;
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Cancer Research Online ISSN: 1538-7445
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