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Inhibition of in Vitro Ovarian Cancer Cell Invasion by Modulation of Urokinase-type Plasminogen Activator and Cathepsin B

Hiroshi Kobayashi, Hidekazu Ohi, Motoi Sugimura, Hiromitsu Shinohara, Toshiro Fujii and Toshihiko Terao
Hiroshi Kobayashi
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Hidekazu Ohi
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Motoi Sugimura
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Hiromitsu Shinohara
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Toshiro Fujii
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Toshihiko Terao
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DOI:  Published July 1992
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Abstract

HOC-I ovarian cancer cells express the single-chain form of the urokinase-type plasminogen activator (uPA) and cathepsin B (cath B) on their cell surface. The significance of the expression of cell surface uPA/cath B activity to the invasive potential was examined by preincubating with uPA/cath B-modulating agents in in vitro invasion assay. The anti-uPA monoclonal antibody 394 effectively inhibited invasion in a dose-dependent manner. On the contrary, anti-cath B antibody did not affect the invasive potential of the cells. E-64, a specific inhibitor for cysteine proteases, blocked invasion as effectively as monoclonal antibody 394. The data reveal that the uPA and cysteine proteases contribute significantly to the invasive capacity of the cells. We suggest that the cysteine proteases facilitate the action of uPA, possibly by activating proenzyme uPA produced by cancer cells. Evidence for the role of a cathepsin-uPA activation cascade in HOC-I cell invasion is provided.

Footnotes

  • ↵1 To whom requests for reprints should be addressed.

  • Received February 7, 1992.
  • Accepted April 24, 1992.
  • ©1992 American Association for Cancer Research.
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July 1992
Volume 52, Issue 13
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Inhibition of in Vitro Ovarian Cancer Cell Invasion by Modulation of Urokinase-type Plasminogen Activator and Cathepsin B
Hiroshi Kobayashi, Hidekazu Ohi, Motoi Sugimura, Hiromitsu Shinohara, Toshiro Fujii and Toshihiko Terao
Cancer Res July 1 1992 (52) (13) 3610-3614;

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Inhibition of in Vitro Ovarian Cancer Cell Invasion by Modulation of Urokinase-type Plasminogen Activator and Cathepsin B
Hiroshi Kobayashi, Hidekazu Ohi, Motoi Sugimura, Hiromitsu Shinohara, Toshiro Fujii and Toshihiko Terao
Cancer Res July 1 1992 (52) (13) 3610-3614;
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