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Carcinogenicity Studies of Fluoxetine Hydrochloride in Rats and Mice

Raymond A. Bendele, Elizabeth R. Adams, Wherly P. Hoffman, Christian L. Gries and Douglas M. Morton
Raymond A. Bendele
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Elizabeth R. Adams
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Wherly P. Hoffman
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Christian L. Gries
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Douglas M. Morton
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DOI:  Published December 1992
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Abstract

The antidepressant drug fluoxetine HCl was tested for carcinogenicity in three well designed and controlled studies in Fischer rats and C57BL/6 × C3H F1 mice. The compound was administered to the animals for 24 months at dietary doses of approximately 0, 0.5, 2.0, or 10.0 mg/kg body weight in rats and 1.0, 5.0, or 10.0 mg/kg in mice. The highest dose tested was a maximum tolerated dose for both species as evidenced by clinical signs (rats and mice) and some mortality (mice) referable to central nervous system pharmacological effects, decreased weight gain (rats), and histopathological changes of phospholipidosis (rats) and hepatic fatty change (mice). There was no evidence of an increased incidence of any type of unusual or commonly occurring spontaneous neoplasm in either rats or mice. There were statistically significant decreases in a few commonly occurring neoplasms. The data reported herein provide convincing evidence that fluoxetine is neither a complete carcinogen nor a tumor promoter.

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • Received September 28, 1992.
  • Accepted October 27, 1992.
  • ©1992 American Association for Cancer Research.
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December 1992
Volume 52, Issue 24
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Carcinogenicity Studies of Fluoxetine Hydrochloride in Rats and Mice
Raymond A. Bendele, Elizabeth R. Adams, Wherly P. Hoffman, Christian L. Gries and Douglas M. Morton
Cancer Res December 15 1992 (52) (24) 6931-6935;

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Carcinogenicity Studies of Fluoxetine Hydrochloride in Rats and Mice
Raymond A. Bendele, Elizabeth R. Adams, Wherly P. Hoffman, Christian L. Gries and Douglas M. Morton
Cancer Res December 15 1992 (52) (24) 6931-6935;
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