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A Gene from Human Chromosome Region 3p21 with Reduced Expression in Small Cell Lung Cancer

Ben Carritt, Klaas Kok, Anke van den Berg, Jan Osinga, Alison Pilz, Robert M. W. Hofstra, Mary B. Davis, Anneke Y. van der Veen, Pamela H. Rabbitts, Kiran Gulati and Charles H. C. M. Buys
Ben Carritt
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Klaas Kok
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Anke van den Berg
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Jan Osinga
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Alison Pilz
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Robert M. W. Hofstra
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Mary B. Davis
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Anneke Y. van der Veen
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Pamela H. Rabbitts
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Kiran Gulati
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Charles H. C. M. Buys
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DOI:  Published March 1992
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Abstract

A combination of cytogenetic and molecular studies has implicated the p21 region of human chromosome 3 as the probable site of a gene the loss of which contributes to the development of small cell lung cancer. We report here the isolation of a gene from this region which is expressed in normal lung tissue and in cell lines derived from a number of different types of tumor, but the expression of which in small cell lung cancer cell lines is undetectable by RNA blot analysis. Although the more sensitive polymerase chain reaction did detect transcripts, a novel quantitative polymerase chain reaction assay showed that their concentration in small cell lung cancer cell lines is less than 3% of that in normal lung.

Footnotes

  • ↵1 This work was supported in part by the Dutch Cancer Society.

  • Received September 6, 1991.
  • Accepted January 7, 1992.
  • ©1992 American Association for Cancer Research.
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March 1992
Volume 52, Issue 6
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A Gene from Human Chromosome Region 3p21 with Reduced Expression in Small Cell Lung Cancer
Ben Carritt, Klaas Kok, Anke van den Berg, Jan Osinga, Alison Pilz, Robert M. W. Hofstra, Mary B. Davis, Anneke Y. van der Veen, Pamela H. Rabbitts, Kiran Gulati and Charles H. C. M. Buys
Cancer Res March 15 1992 (52) (6) 1536-1541;

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A Gene from Human Chromosome Region 3p21 with Reduced Expression in Small Cell Lung Cancer
Ben Carritt, Klaas Kok, Anke van den Berg, Jan Osinga, Alison Pilz, Robert M. W. Hofstra, Mary B. Davis, Anneke Y. van der Veen, Pamela H. Rabbitts, Kiran Gulati and Charles H. C. M. Buys
Cancer Res March 15 1992 (52) (6) 1536-1541;
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Cancer Research Online ISSN: 1538-7445
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