Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Advances in Brief

Interstitial Pressure of Subcutaneous Nodules in Melanoma and Lymphoma Patients: Changes during Treatment

Brendan D. Curti, Walter J. Urba, W. Gregory Alvord, John E. Janik, John W. Smith II, Karen Madara and Dan L. Longo
Brendan D. Curti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter J. Urba
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. Gregory Alvord
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John E. Janik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John W. Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karen Madara
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dan L. Longo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published May 1993
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Interstitial pressure (IP) is a physiological variable that may have its greatest influence on the transport of high-molecular-weight therapeutic agents. IP in tumor nodules was measured in patients with metastatic melanoma or non-Hodgkin's lymphoma to determine the influence of this physiological variable on treatment outcome. The wick-in-needle technique was used to measure IP at time points before and after treatment with a variety of immunotherapy and chemotherapy regimens. Selected patients had IP measurements during chemotherapy or immunotherapy infusions. Ultrasound or computed tomography was used to evaluate the size of the studied lesions and their relationship to normal structures. The mean baseline IP in melanoma nodules (n = 22) and lymphoma nodules (n = 7) was 29.8 and 4.7 mm Hg, respectively (P = 0.013 for the difference between tumor types). In a subset of melanoma nodules for which IP had been measured before and after treatment, the IP increased significantly over time for nonresponding melanoma lesions from a baseline of 24.4 to 53.9 mm Hg after treatment (P = 0.005) and decreased in melanoma lesions that responded to treatment where the mean baseline and post-treatment IPs were 12.2 and 0 mm Hg, respectively (P = 0.001 for the difference in IP profiles between responding and nonresponding lesions). Six of seven lymphoma nodules responded completely to chemotherapy or radiation. The single nodule that did not respond had a baseline IP of 1 mm Hg that increased to 30 mm Hg after treatment. Tumor IP differs significantly between melanoma and non-Hodgkin's lymphoma. The changes in IP over time differ significantly between responding and non-responding melanoma lesions. IP that increases during treatment appears to be associated with tumor progression in these tumor types.

Footnotes

  • ↵1 The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

  • ↵2 To whom requests for reprints should be addressed, at Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute-Frederick Cancer Research and Development Center, 501 W. Seventh Street, Suite 3, Frederick, MD 21701.

  • Received February 10, 1993.
  • Accepted April 1, 1993.
  • ©1993 American Association for Cancer Research.
PreviousNext
Back to top
May 1993
Volume 53, Issue 10
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Interstitial Pressure of Subcutaneous Nodules in Melanoma and Lymphoma Patients: Changes during Treatment
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Interstitial Pressure of Subcutaneous Nodules in Melanoma and Lymphoma Patients: Changes during Treatment
Brendan D. Curti, Walter J. Urba, W. Gregory Alvord, John E. Janik, John W. Smith II, Karen Madara and Dan L. Longo
Cancer Res May 15 1993 (53) (10) 2204-2207;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Interstitial Pressure of Subcutaneous Nodules in Melanoma and Lymphoma Patients: Changes during Treatment
Brendan D. Curti, Walter J. Urba, W. Gregory Alvord, John E. Janik, John W. Smith II, Karen Madara and Dan L. Longo
Cancer Res May 15 1993 (53) (10) 2204-2207;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Advances in Brief

  • Crucial Role of Phospholipase Cε in Chemical Carcinogen-Induced Skin Tumor Development
  • Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors
  • Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
Show more 3

Articles

  • Imprinting of a Genomic Domain of 11p15 and Loss of Imprinting in Cancer: An Introduction
  • Introduction of Stanley J. Korsmeyer
  • Organizational Structure: General Motors Cancer Research Foundation
Show more 3
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement