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Molecular Biology and Genetics

Deletion of 1p36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis

Georgia Bardi, Nikos Pandis, Claus Fenger, Ole Kronborg, Lilian Bomme and Sverre Heim
Georgia Bardi
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Nikos Pandis
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Claus Fenger
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Ole Kronborg
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Lilian Bomme
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Sverre Heim
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DOI:  Published April 1993
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Abstract

Cytogenetic analysis of short-term cultures from benign intestinal tumors revealed clonal chromosome aberrations in five colorectal adenomas, one adenoma of the papilla Vateri, and one hyperplastic polyp of the rectum. One adenoma had numerical aberrations only, but in all other tumors structural rearrangements were found that led to loss of genetic material from 1p. In three of the cases, the deletion was restricted to the 1p36 band; the rest had lost larger 1p segments. The rearrangement of chromosome 1 was the sole karyotypic anomaly in three adenomas, all with mild or moderate dysplasia, and in the hyperplastic polyp. Both adenomas that had additional aberrations beyond the 1p loss showed severe dysplasia. We conclude that cytogenetically detectable loss of genetic information from 1p36 is an early, seemingly primary, premalignant event in intestinal tumorigenesis. The fact that the adenomas with 1p-as the sole change showed only mild or moderate dysplasia and that the del(1p) was found also in the hyperplastic polyp suggests that this aberration is more related to the induction of hyperproliferation than to differentiation disturbances in the intestinal mucosa.

Footnotes

  • ↵1 Supported by the Commission of the European Communities (Medical Research Programme) and the Danish Cancer Society. Drs. Bardi and Pandis are on leave from the Papanikolaou Research Center, Hellenic Anticancer Institute, Athens, Greece.

  • ↵2 To whom requests for reprints should be addressed.

  • Received November 10, 1992.
  • Accepted February 9, 1993.
  • ©1993 American Association for Cancer Research.
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April 1993
Volume 53, Issue 8
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Deletion of 1p36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis
Georgia Bardi, Nikos Pandis, Claus Fenger, Ole Kronborg, Lilian Bomme and Sverre Heim
Cancer Res April 15 1993 (53) (8) 1895-1898;

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Deletion of 1p36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis
Georgia Bardi, Nikos Pandis, Claus Fenger, Ole Kronborg, Lilian Bomme and Sverre Heim
Cancer Res April 15 1993 (53) (8) 1895-1898;
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