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Immunomodulation in Patients with Epithelial Ovarian Cancer after Adoptive Transfer of Tumor-infiltrating Lymphocytes

Hirokazu Ikarashi, Kazuyuki Fujita, Kouichi Takakuwa, Shoji Kodama, Akiteru Tokunaga, Takeshi Takahashi and Kenichi Tanaka
Hirokazu Ikarashi
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Kazuyuki Fujita
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Kouichi Takakuwa
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Shoji Kodama
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Akiteru Tokunaga
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Takeshi Takahashi
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Kenichi Tanaka
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DOI:  Published January 1994
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Abstract

The immunomodulation determined by natural killer cell activity, delayed-type hypersensitivity to purified protein derivative and phytohemagglutin, and phenotypic changes of peripheral blood lymphocytes was characterized in 12 patients with epithelial ovarian cancer who received adoptive transfer of tumor-infiltrating lymphocytes (TILs) after cisplatin-containing chemotherapy (TIL group). As a control, 10 patients with epithelial ovarian cancer who did not receive infusions of TIL were also examined in the same fashion. In the TIL group, peripheral blood lymphocytes showed increased percentages of cells bearing the CD8 antigen, in contrast to stable percentages of CD4 antigen-bearing cells, resulting in a decreased ratio of CD4+ to CD8+ cells. The percentages of CD16 and CD56 antigen-bearing cells also increased in proportion to augmentation of natural killer cell activity against K562 cells. Additionally, with regard to cell-mediated immunity determined by delayed-type hypersensitivity to phytohemagglutin and purified protein derivative, significantly and slightly enlarged erythema was observed 2 and 8 weeks, respectively, after the injection of TILs (phytohemagglutin, P < 0.05; purified protein derivative, not statistically significant). The control group showed no major changes in any of the immunological markers. These results suggest the possibility that the adoptive transfer of TILs induces immunoactivation of cellular immunity and enhances natural killer activity in patients with epithelial ovarian cancer.

Footnotes

  • ↵1 This work was supported in part by a grant-in-aid from the Ministry of Health and Welfare for the Comprehensive 10-Year Strategy for Cancer Control.

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • Received November 24, 1992.
  • Accepted October 25, 1993.
  • ©1994 American Association for Cancer Research.
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January 1994
Volume 54, Issue 1
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Immunomodulation in Patients with Epithelial Ovarian Cancer after Adoptive Transfer of Tumor-infiltrating Lymphocytes
Hirokazu Ikarashi, Kazuyuki Fujita, Kouichi Takakuwa, Shoji Kodama, Akiteru Tokunaga, Takeshi Takahashi and Kenichi Tanaka
Cancer Res January 1 1994 (54) (1) 190-196;

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Immunomodulation in Patients with Epithelial Ovarian Cancer after Adoptive Transfer of Tumor-infiltrating Lymphocytes
Hirokazu Ikarashi, Kazuyuki Fujita, Kouichi Takakuwa, Shoji Kodama, Akiteru Tokunaga, Takeshi Takahashi and Kenichi Tanaka
Cancer Res January 1 1994 (54) (1) 190-196;
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