Abstract
In human leukemia, activation of the ABL proto-oncogene locus on chromosome 9 most commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel activation of ABL which involves a gene located on chromosome 12, designated TEL. Like BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated tyrosine kinase activity when assayed in an immune complex. The amino-terminal sequences of TEL encode a helix-loop-helix motif which may mediate dimerization.
Footnotes
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↵1 This work was supported by the Leukaemia Research Fund of Great Britain and the Deutsche Krebshilfe.
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↵3 To whom requests for reprints should be addressed.
- Received October 28, 1994.
- Accepted November 16, 1994.
- ©1995 American Association for Cancer Research.
Volume 55, Issue 1
