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Advances in Brief

Tamoxifen-induced DNA Adducts in Endometrial Samples from Breast Cancer Patients

Kari Hemminki, Heli Rajaniemi, Bengt Lindahl and Birgitta Moberger
Kari Hemminki
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Heli Rajaniemi
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Bengt Lindahl
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Birgitta Moberger
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DOI:  Published October 1996
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Abstract

Tamoxifen-induced DNA adducts were analyzed with the 32P-postlabeling method using high-performance liquid chromatography (HPLC)-radioactivity detection from endometrial tissue of breast cancer patients and controls. Liver DNA from tamoxifen-treated rats was used as a positive standard. In blind analysis, five of the seven samples from tamoxifen-treated patients showed DNA adducts; none of the five controls were positive. The identity of the tamoxifen adduct was confirmed by using different chromatographic systems, isolating the HPLC fractions and running them on TLC, with or without spiked rat liver samples. The level of adducts in the treated patients was 2.7 adducts/109 nucleotides in the HPLC analysis.

Footnotes

  • ↵1 This study was supported by the Swedish Cancer Fund and the Orion-Farmos Company. Presented at the meeting DNA Adducts and Mutations in Human Biomonitoring, Huddinge, Sweden, June 1996.

  • ↵2 To whom requests for reprints should be addressed. Phone: 46-8-6089243; Fax: 46-8-6081501.

  • Received July 1, 1996.
  • Accepted August 15, 1996.
  • ©1996 American Association for Cancer Research.
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October 1996
Volume 56, Issue 19
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Tamoxifen-induced DNA Adducts in Endometrial Samples from Breast Cancer Patients
Kari Hemminki, Heli Rajaniemi, Bengt Lindahl and Birgitta Moberger
Cancer Res October 1 1996 (56) (19) 4374-4377;

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Tamoxifen-induced DNA Adducts in Endometrial Samples from Breast Cancer Patients
Kari Hemminki, Heli Rajaniemi, Bengt Lindahl and Birgitta Moberger
Cancer Res October 1 1996 (56) (19) 4374-4377;
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Cancer Research Online ISSN: 1538-7445
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