Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Advances in Brief

Loss of Chromosome 18q Is an Early Event in Pancreatic Ductal Tumorigenesis

Shinichi Fukushige, Toru Furukawa, Kennichi Satoh, Makoto Sunamura, Masao Kobari, Masaru Koizumi and Akira Horii
Shinichi Fukushige
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toru Furukawa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kennichi Satoh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Makoto Sunamura
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masao Kobari
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masaru Koizumi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akira Horii
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published October 1998
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Cytogenetic and molecular studies demonstrated that pancreatic cancer frequently shows specific chromosomal abnormalities, such as losses of 9p, 17p, and 18q, and gains of 8q and 20q. We have analyzed alterations in the copy number of specific chromosomal regions in cells from the pancreatic juices of 32 patients with various pancreatic disorders by fluorescence in situ hybridization (FISH) technique to pursue the possible clinical use of early diagnosis of pancreatic cancer. None of the chromosomal abnormalities were found in 13 specimens from individuals who had no neoplastic lesions. On the other hand, 12 specimens (63%) derived from the remaining 19 patients who had neoplastic lesions showed at least one chromosomal abnormality. Ten of these specimens were from pancreatic cancer patients; 7 cases (70%) showed chromosomal abnormalities. All but one of the 12 tumors with chromosomal abnormalities had loss of 18q. Furthermore, we detected a tumor in one patient in whom the routine cytological method and endoscopic retrograde chorangiopancreatography found nothing. Based on the results by FISH, we performed endoscopic ultrasonography and found a small serous cystadenoma in this patient. These results indicate that: (a) FISH analysis of cells from pancreatic juices obtained during endoscopic retrograde chorangiopancreatography is quite useful for detecting pancreatic ductal tumors; and (b) loss of chromosome 18q is one of the early genetic changes that provide very useful information in diagnosing pancreatic neoplasias.

Footnotes

  • ↵1 This work was supported by Japanese Ministries of Education, Science, Sports and Culture, and Health and Welfare, Public Trust Haraguchi Memorial Cancer Research Fund, Terumo Life Science Foundation, Mitsui Life Social Welfare Foundation, Pancreas Research Foundation of Japan, and the Sagawa Foundation for Promotion of Cancer Research.

  • ↵2 To whom requests for reprints should be addressed. Phone: 81-22-717-8042; Fax: 81-22-717-8047; E-mail: horii@mail.cc.tohoku.ac.jp.

  • Received June 12, 1998.
  • Accepted August 11, 1998.
  • ©1998 American Association for Cancer Research.
PreviousNext
Back to top
October 1998
Volume 58, Issue 19
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Loss of Chromosome 18q Is an Early Event in Pancreatic Ductal Tumorigenesis
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Loss of Chromosome 18q Is an Early Event in Pancreatic Ductal Tumorigenesis
Shinichi Fukushige, Toru Furukawa, Kennichi Satoh, Makoto Sunamura, Masao Kobari, Masaru Koizumi and Akira Horii
Cancer Res October 1 1998 (58) (19) 4222-4226;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Loss of Chromosome 18q Is an Early Event in Pancreatic Ductal Tumorigenesis
Shinichi Fukushige, Toru Furukawa, Kennichi Satoh, Makoto Sunamura, Masao Kobari, Masaru Koizumi and Akira Horii
Cancer Res October 1 1998 (58) (19) 4222-4226;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Advances in Brief

  • Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors
  • Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
  • Recombinant Listeria Vaccines Containing PEST Sequences Are Potent Immune Adjuvants for the Tumor-Associated Antigen Human Papillomavirus-16 E7
Show more 3

Articles

  • Id Gene Expression as a Key Mediator of Tumor Cell Biology
  • Multiple Roles for the Wilms' Tumor Suppressor, WT1
  • Radiation Biology and Treatment Options in Radiation Oncology
Show more 3
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement