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Educational Session: Chromatin Structure and Function in Cancer

Network-like properties of chromatin: Implications for basic science and opportunities for clinical application.

Bradley E. Bernstein and Stuart L. Schreiber
Bradley E. Bernstein
Harvard University Chemistry & Chemical Biology and Brigham & Women’s Pathology, Cambridge, MA and Harvard University Chemistry & Chemical Biology, Cambridge, MA
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Stuart L. Schreiber
Harvard University Chemistry & Chemical Biology and Brigham & Women’s Pathology, Cambridge, MA and Harvard University Chemistry & Chemical Biology, Cambridge, MA
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DOI:  Published April 2004
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Proc Amer Assoc Cancer Res, Volume 45, 2004

Abstract

Common principles underlie cellular signaling networks and chromatin. For example, post-translational modifications of receptor tyrosine kinases and histone proteins both create docking sites that recruit downstream proteins. In each case, multiple modifications combine to promote switch-like behavior and ensure robustness of the signal. These network-like properties provide insight into heterochromatin propagation and epigenetic memory, and have implications for drug discovery.

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April 2004
Volume 64, Issue 7 Supplement
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Network-like properties of chromatin: Implications for basic science and opportunities for clinical application.
Bradley E. Bernstein and Stuart L. Schreiber
Cancer Res April 1 2004 (64) (7 Supplement) 1306;

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Network-like properties of chromatin: Implications for basic science and opportunities for clinical application.
Bradley E. Bernstein and Stuart L. Schreiber
Cancer Res April 1 2004 (64) (7 Supplement) 1306;
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
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