Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Endocrinology 4: Endocrinology IV

The steroid receptor RNA activator (SRA) encodes a protein conserved in vertebrates

Shilpa K. Chooniedass, Sandra Troup, Mohammad K. Hamedani, Magdalena Drewniak, Anna Czosnek, Xuemei Wang and Etienne Leygue
Shilpa K. Chooniedass
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sandra Troup
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mohammad K. Hamedani
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Magdalena Drewniak
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Czosnek
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xuemei Wang
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Etienne Leygue
University of Manitoba, Winnipeg, MB, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published April 2004
  • Article
  • Info & Metrics
Loading
Proc Amer Assoc Cancer Res, Volume 45, 2004

Abstract

2872

Steroid receptor RNA activator (SRA) is a steroid receptor co-activator that has recently been shown to enhance estrogen induced transcriptional activity of estrogen receptors alpha and beta. SRA differs from the other steroid receptor co-activators, in that it was shown to function as a non-coding RNA molecule. The initial paper on SRA reported a lack of success in generating any in vitro or in vivo stable SRA protein. We have identified three SRA RNA isoforms sequences which, unlike the previously described non-coding RNA, have a longer 5’ end and encode a stable SRA protein. Through database analyses, we have also identified mRNA sequences of SRA for several classes of vertebrates. Analysis of the protein sequences showed that the SRA protein family members are similar in size and have two extremely well conserved regions. Using an SRA antibody targeted against the N-terminal conserved region of the protein and muscle extracts from different vertebrate species, we have detected in a protein band of similar size. In MCF-7 cells stably transfected with SRA cDNA, we unexpectedly found that ER alpha activity is reduced in the presence of estradiol compared to non-transfected cells. Therefore our results suggest a possible role for SRA protein that is distinct from the SRA RNA.

  • American Association for Cancer Research
Previous
Back to top
April 2004
Volume 64, Issue 7 Supplement
  • Table of Contents
  • Index by Author

Sign up for alerts

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The steroid receptor RNA activator (SRA) encodes a protein conserved in vertebrates
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
The steroid receptor RNA activator (SRA) encodes a protein conserved in vertebrates
Shilpa K. Chooniedass, Sandra Troup, Mohammad K. Hamedani, Magdalena Drewniak, Anna Czosnek, Xuemei Wang and Etienne Leygue
Cancer Res April 1 2004 (64) (7 Supplement) 662;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The steroid receptor RNA activator (SRA) encodes a protein conserved in vertebrates
Shilpa K. Chooniedass, Sandra Troup, Mohammad K. Hamedani, Magdalena Drewniak, Anna Czosnek, Xuemei Wang and Etienne Leygue
Cancer Res April 1 2004 (64) (7 Supplement) 662;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Role of estrogen receptors alpha and beta in human lung cancer
  • Regulation of nuclear receptor interacting protein (NRIP1/RIP140) by estrogen
  • Steroid coactivator GRIP-1 regulation with genistein in the rat mammary gland
Show more Endocrinology 4: Endocrinology IV
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement