Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Tumor Biology 12: Animal Models 4: Genitourinary and Gastrointestinal

Pro-oxidant enzyme Nox-1 over expression in TRAMP prostate cancer murine model reflects clinical findings

John A. Petros, David Martin, Milton Datta and Rebecca S. Arnold
John A. Petros
Emory University School of Medicine, Atlanta, GA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Martin
Emory University School of Medicine, Atlanta, GA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Milton Datta
Emory University School of Medicine, Atlanta, GA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rebecca S. Arnold
Emory University School of Medicine, Atlanta, GA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published May 2005
  • Article
  • Info & Metrics
Loading
Proc Amer Assoc Cancer Res, Volume 46, 2005

Abstract

1970

Nox-1 is a membrane-bound NADPH oxidase that generates superoxide anion. We have previously reported that 80% of human prostate cancers exhibit cancer-specific over expression of both Nox-1 mRNA and protein (2004). Furthermore, we have demonstrated that experimental over expression on Nox-1 in the DU-145 prostate cancer cell line markedly increases reactive oxygen species (ROS), angiogenesis and tumor growth (2001). Others have shown that antioxidants block prostate cancer in SV-40 transgenic mice (2004). We therefore evaluated the TRAMP mouse model of prostate cancer for Nox-1 expression in order to identify an appropriate model for this molecular alteration observed so commonly in human prostate cancer. At 10 weeks of age TRAMP mice and wild type mice have the same level of Nox-1 mRNA expression, however by 18 weeks, half of the mice demonstrate increased Nox-1 expression in the prostate despite a normal appearing gland. By 25-30 weeks, approximately 70% of TRAMP prostates express increased levels of Nox-1 message using quantitative RT-PCR. Other Nox isoforms, including Nox-4 show no consistent difference in wild type and transgenic prostates. The TRAMP model of murine prostate cancer may therefore be an appropriate model system to evaluate the role Nox-1 over expression plays in prostate carcinogenesis. Because the transgenic prostates initially express normal levels of Nox-1 this may be an appropriate model to study Nox-1 transcription regulation, a control point particularly relevant to human tumors.

  • American Association for Cancer Research
Previous
Back to top
Cancer Research: 65 (9 Supplement)
May 2005
Volume 65, Issue 9 Supplement
  • Table of Contents
  • Index by Author

Sign up for alerts

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Pro-oxidant enzyme Nox-1 over expression in TRAMP prostate cancer murine model reflects clinical findings
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Pro-oxidant enzyme Nox-1 over expression in TRAMP prostate cancer murine model reflects clinical findings
John A. Petros, David Martin, Milton Datta and Rebecca S. Arnold
Cancer Res May 1 2005 (65) (9 Supplement) 461;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Pro-oxidant enzyme Nox-1 over expression in TRAMP prostate cancer murine model reflects clinical findings
John A. Petros, David Martin, Milton Datta and Rebecca S. Arnold
Cancer Res May 1 2005 (65) (9 Supplement) 461;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Xenografts of human hepatocellular carcinoma: A tool for screening drugs used in treatment of this disease
  • Further genetic manipulations of the Pten conditional deletion mouse model of prostate cancer
  • Prostate-specific deletion of Apc leads to early onset prostate cancer
Show more Tumor Biology 12: Animal Models 4: Genitourinary and Gastrointestinal
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement