Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Cellular and Molecular Biology 40: TGFβ and Wnt Signaling Pathways

Hedgehog signal activation in esophageal epithelium and in tumor

Noriyuki Isohata, Masahide Fukaya, Hiroyuki Ohta, Kazuhiko Aoyagi, Hiroyuki Daiko, Yukihiro Nakanishi, Kazuhiko Yoshimatsu, Kenji Ogawa, Teruhiko Yoshida and Hiroki Sasaki
Noriyuki Isohata
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masahide Fukaya
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroyuki Ohta
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuhiko Aoyagi
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroyuki Daiko
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yukihiro Nakanishi
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuhiko Yoshimatsu
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenji Ogawa
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Teruhiko Yoshida
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroki Sasaki
National Cancer Center Research Institute, Tokyo, Japan and Tokyo Women’s Medical University, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published April 2006
  • Article
  • Info & Metrics
Loading
Proc Amer Assoc Cancer Res, Volume 47, 2006

Abstract

2674

Background & Aims: It has been established that Hedgehog ( Hh ) signal acts on both embryonal development and homeostasis and differentiation of the various adult tissue. However, in the esophagus, Hh signal activation remain unclear. In this study, we investigated whether Hh signal pathway is activated in the esophageal epithelium and tumors. Methods: By RT-PCR and immunohistochemical analysis, we investigated expression of many Hh signaling molecules in three layers of epithelium, the basal, epibasal, and differentiated, and also in esophageal squamous cell carcinomas ( ESCCs ). The effect of a Hh-pathway-specific inhibitor cyclopamine on a mouse primary culture and human esophageal cancer cell lines was investigated. Results: Hh signal activation through SHH and DHH was found in the basal and epibasal cells but not in the differentiated cells. Inhibition of the Hh signaling by cyclopamine in the mouse primary culture resulted in a decrease of differentiated cells. In ESCCs, 80% showed Hh signal activation through not only SHH and DHH expression but also cancer-linked IHH expression, and 17% showed that through a ligand free mechanism. Cyclopamine treatment inhibited cell growth of Hh signal-activated ESCCs. Conclusions: All the present data suggest that the Hh signal activation is required for esophageal epithelial cell differentiation, and that most ESCCs showed Hh signal activation. This type of cancer could be a therapeutic target of the Hh-pathway-specific inhibitors.

  • American Association for Cancer Research
Previous
Back to top
Cancer Research: 66 (8 Supplement)
April 2006
Volume 66, Issue 8 Supplement
  • Table of Contents
  • Index by Author

Sign up for alerts

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Hedgehog signal activation in esophageal epithelium and in tumor
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Hedgehog signal activation in esophageal epithelium and in tumor
Noriyuki Isohata, Masahide Fukaya, Hiroyuki Ohta, Kazuhiko Aoyagi, Hiroyuki Daiko, Yukihiro Nakanishi, Kazuhiko Yoshimatsu, Kenji Ogawa, Teruhiko Yoshida and Hiroki Sasaki
Cancer Res April 15 2006 (66) (8 Supplement) 629;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Hedgehog signal activation in esophageal epithelium and in tumor
Noriyuki Isohata, Masahide Fukaya, Hiroyuki Ohta, Kazuhiko Aoyagi, Hiroyuki Daiko, Yukihiro Nakanishi, Kazuhiko Yoshimatsu, Kenji Ogawa, Teruhiko Yoshida and Hiroki Sasaki
Cancer Res April 15 2006 (66) (8 Supplement) 629;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Snail transcription factor regulates TGF-b1 mediated MMP-9 expression in oral squamous carcinoma cells
  • The role of Notch in head and neck squamous cell carcinoma
  • Characterization of Sonic Hedgehog expression and Hedgehog pathway activity in Barrett’s esophagus and esophageal adenocarcinoma
Show more Cellular and Molecular Biology 40: TGFβ and Wnt Signaling Pathways
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement