Abstract
2387
Neuroblastomas are highly lethal tumors and 85% of cerebral neuroblastoma occurs in children and 15% in adults. Neuroblastoma is the fourth most common type of cancer in children. According to the American Cancer Society, there are approximately 650 new cases of neuroblastoma each year in the United States. Despite significant educational efforts, improved diagnostic techniques, and rigorous therapies, neuroblastoma control remains static. To address this health issue, the objectives of this research was to investigate the use protein kinase C-iota (PKC-ι) inhibitors on the proliferation of neuroblastoma cells. Previous work has shown that inhibition of PKC-ι is a promising means by which to prevent and treat certain cancers. Here, we report the identification of a PKC-ι inhibitor (1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy) methyl]cyclopentyl]-,[1R-(1α, 2β, 3β, 4α)] (ICA-1) that targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKC-ι, inhibits PKC-ι activity and is effective in blocking the proliferation of BE(2)C neuroblastoma cells. Our data support significant proof of concept that ICA-1 inhibits the proliferation of neuroblastoma cells and may be a novel chemotherapeutic for the treatment of patients with neuroblastoma.
Footnotes
99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA
- American Association for Cancer Research