Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Epidemiology

Abstract #2126: Polymorphisms of the one-carbon metabolism related genes and aberrant CpG island hypermethylation in prostate cancer

Masatoshi Watanabe, Yoshifumi Hirokawa, Hiroyoshi Suzuki, Tomohiko Ichikawa, Takahiko Katoh, Yoshiki Sugimura and Taizo Shiraishi
Masatoshi Watanabe
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshifumi Hirokawa
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroyoshi Suzuki
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomohiko Ichikawa
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takahiko Katoh
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshiki Sugimura
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Taizo Shiraishi
Yokohama National Univ., Yokohama, Japan; Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Japan; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Public Health, Graduate school of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Urology, Mie University Graduate School of Medicine, Tsu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published May 2009
  • Article
  • Info & Metrics
Loading
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Abstract

Many molecular studies have indicated that genetic and epigenetic alterations are important for carcinogenesis in the prostate. Alterations in the one-carbon metabolism pathway can influence DNA synthesis and DNA methylation. Polymorphisms in the genes for the methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), serine hydroxymethyltransferase (SHMT) have been reported to be associated with some forms of malignancies. In a case-control study of 200 cases and 240 controls, we investigated whether four common polymorphisms in the MTHFR (C677T and A1298T), MTR (A2756G), SHMT1 (C1420T), MTRR (A66G), cystathione-\#946;-synthase (CBS, 844ins68), and reduced folate carrier (RFC-1, A80G) may have a role in altering prostate cancer susceptibility. The genotype was mainly determined by the PCR-RFLP method. The MTHFR C677T genotype was associated with a significant decrease in the risk with an adjusted odds ratio of 0.50 (95% confidence interval: 0.27-0.92). However, the MTHFR A1298C, MTR A2756G and SHMT1 C1420T, MTRR A66G, CBS and RFC-1 were not associated with prostate cancer risk. We also analyzed CpG island hypermethylation in five genes (GSTP1, RAR\#946;2, AR, DAPK, TIMP-3 and hMLH1) and its association with four polymorphisms in 50 prostate cancers. The MTHFR A1298C was significantly associated with AR methylation status. These findings suggest that polymorphisms of the MTHFR may be involved in carcinogenesis of the prostate.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2126.

Footnotes

  • 100th AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

  • American Association for Cancer Research
Back to top
Cancer Research: 69 (9 Supplement)
May 2009
Volume 69, Issue 9 Supplement
  • Table of Contents
  • Index by Author

Sign up for alerts

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Abstract #2126: Polymorphisms of the one-carbon metabolism related genes and aberrant CpG island hypermethylation in prostate cancer
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
Abstract #2126: Polymorphisms of the one-carbon metabolism related genes and aberrant CpG island hypermethylation in prostate cancer
Masatoshi Watanabe, Yoshifumi Hirokawa, Hiroyoshi Suzuki, Tomohiko Ichikawa, Takahiko Katoh, Yoshiki Sugimura and Taizo Shiraishi
Cancer Res May 1 2009 (69) (9 Supplement) 2126;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Abstract #2126: Polymorphisms of the one-carbon metabolism related genes and aberrant CpG island hypermethylation in prostate cancer
Masatoshi Watanabe, Yoshifumi Hirokawa, Hiroyoshi Suzuki, Tomohiko Ichikawa, Takahiko Katoh, Yoshiki Sugimura and Taizo Shiraishi
Cancer Res May 1 2009 (69) (9 Supplement) 2126;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
Advertisement

Related Articles

Cited By...

More in this TOC Section

Epidemiology

  • Abstract SY32-02: Genetic architecture of cancer and other complex diseases: Lessons learned and future directions
  • Abstract SY07-04: Diet and xenobiotic-metabolizing enzymes: Learning from controlled feeding studies in humans
  • Abstract SY08-01: Cancer in immunosuppressed populations: Epidemiologic clues to causation
Show more 3

Candidate Genes and Risk of Gastrointestinal and Prostate Cancers -- Poster Presentations - Proffered Abstracts

  • Abstract #2127: Association of SNPs in lympha/angiogenesis genes with prostate cancer risk.
  • Abstract #2106: Genetic susceptibility to esophageal adenocarcinoma
  • Abstract #2113: Sequence variance in genes involved in oxidative stress and risk of pancreatic cancer: Effects modified by alcohol intake
Show more 3
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement