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Cellular and Molecular Biology

Abstract #LB-182: DRAM2 (Damage Regulated Autophagy Regulator 2), a Novel p53 Inducible Transmembrane Protein related to DRAM, regulates autophagy

Ik-Soon Jang, Seung-Hoon Lee and Junsoo Park
Ik-Soon Jang
Korea Basic Science Institute, Taejon, Korea, Republic of; Yong-In University, Yongin, Korea, Republic of; Yonsei University, Wonju, Korea, Republic of
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Seung-Hoon Lee
Korea Basic Science Institute, Taejon, Korea, Republic of; Yong-In University, Yongin, Korea, Republic of; Yonsei University, Wonju, Korea, Republic of
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Junsoo Park
Korea Basic Science Institute, Taejon, Korea, Republic of; Yong-In University, Yongin, Korea, Republic of; Yonsei University, Wonju, Korea, Republic of
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DOI:  Published May 2009
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AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Abstract

Although the role of autophagy in tumorigenesis remains controversial, recent reports support the notion that the inhibition of autophagy promotes tumor promotion. DRAM (damage-regulated autophagy regulator) has been identified as an effector molecule which is critical for p53-mediated apoptosis, and we supposed that there might be other DRAM-like molecules which link autophagy and apoptosis. In this study, we describe the cloning and characterization of a novel DRAM homologue protein, DRAM2. The expression of DRAM2 is down-regulated in tumors, and both amino acid starvation and p53 expression induce DRAM2 expression. Whereas the overexpression of DRAM2 induces autophagy, the silencing of endogenous DRAM2 interferes with starvation-induced autophagy, and also attenuates p53-mediated cell death. Thus, we propose that DRAM2 is a novel DRAM-like transmembrane protein that mediates autophagy.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-182.

Footnotes

  • 100th AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

  • American Association for Cancer Research
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Cancer Research: 69 (9 Supplement)
May 2009
Volume 69, Issue 9 Supplement
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Abstract #LB-182: DRAM2 (Damage Regulated Autophagy Regulator 2), a Novel p53 Inducible Transmembrane Protein related to DRAM, regulates autophagy
Ik-Soon Jang, Seung-Hoon Lee and Junsoo Park
Cancer Res May 1 2009 (69) (9 Supplement) LB-182;

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Abstract #LB-182: DRAM2 (Damage Regulated Autophagy Regulator 2), a Novel p53 Inducible Transmembrane Protein related to DRAM, regulates autophagy
Ik-Soon Jang, Seung-Hoon Lee and Junsoo Park
Cancer Res May 1 2009 (69) (9 Supplement) LB-182;
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Cancer Research Online ISSN: 1538-7445
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