Abstract
We are employing array-based genome-scale siRNA libraries to facilitate a comprehensive analysis of the molecular pressure-points supporting tumorigenic transformation. Genome-wide siRNA-induced synthetic lethality across diverse genetic backgrounds and across multiple chemical perturbations is being used to define both common and lineage-specific loci required to support cancer cell regulatory networks. An emerging theme from these studies is the development of conditional dependencies, in tumor-derived cells, on otherwise anomalous gene products for support of mitotic fidelity. These gene products appear to normalize underlying aberrations in mitotic spindle assembly and function that occur during tumor development and likely represent authentic candidates for therapeutic intervention.
Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr SY08-3.
Footnotes
100th AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO
- American Association for Cancer Research
Volume 69, Issue 9 Supplement
