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Cancer Genomics and Drug Discovery

Abstract #SY08-3: Towards functional annotation of the cancer genome

Angelique Whitehurst, Kakajan Komurov and Michael White
Angelique Whitehurst
University of Texas Southwestern Medical Center, Dallas, TX
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Kakajan Komurov
University of Texas Southwestern Medical Center, Dallas, TX
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Michael White
University of Texas Southwestern Medical Center, Dallas, TX
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DOI:  Published May 2009
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AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Abstract

We are employing array-based genome-scale siRNA libraries to facilitate a comprehensive analysis of the molecular pressure-points supporting tumorigenic transformation. Genome-wide siRNA-induced synthetic lethality across diverse genetic backgrounds and across multiple chemical perturbations is being used to define both common and lineage-specific loci required to support cancer cell regulatory networks. An emerging theme from these studies is the development of conditional dependencies, in tumor-derived cells, on otherwise anomalous gene products for support of mitotic fidelity. These gene products appear to normalize underlying aberrations in mitotic spindle assembly and function that occur during tumor development and likely represent authentic candidates for therapeutic intervention.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr SY08-3.

Footnotes

  • 100th AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

  • American Association for Cancer Research
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Cancer Research: 69 (9 Supplement)
May 2009
Volume 69, Issue 9 Supplement
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Abstract #SY08-3: Towards functional annotation of the cancer genome
Angelique Whitehurst, Kakajan Komurov and Michael White
Cancer Res May 1 2009 (69) (9 Supplement) SY08-3;

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Abstract #SY08-3: Towards functional annotation of the cancer genome
Angelique Whitehurst, Kakajan Komurov and Michael White
Cancer Res May 1 2009 (69) (9 Supplement) SY08-3;
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Cancer Genomics and Drug Discovery

  • Abstract #SY08-1: Functional genomics to identify and validate cancer targets
  • Abstract #SY08-2: Gene expression-based approaches to small molecule discovery for cancer
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Cancer Research Online ISSN: 1538-7445
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