Therapeutics, Targets, and Chemical Biology
Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth
Syng-Ook Lee, Maen Abdelrahim, Kyungsil Yoon, Sudhakar Chintharlapalli, Sabitha Papineni, Kyounghyun Kim, Huamin Wang and Stephen Safe
Cancer Res September 1 2010 70 (17) 6824-6836; DOI:10.1158/0008-5472.CAN-10-1992
Findings offer preclinical validation of a tractable, druggable molecule that has been implicated in the control of cancer cell survival at the levels of transcription as well as switching Bcl-2 function at mitochondria.