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Table of Contents

Breaking Advances

Clinical Studies

  • Clinical Studies
    MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer
    Ananya Choudhury, Louisa D. Nelson, Mark T.W. Teo, Sameer Chilka, Selina Bhattarai, Colin F. Johnston, Faye Elliott, Johanna Lowery, Claire F. Taylor, Michael Churchman, Johanne Bentley, Margaret A. Knowles, Patricia Harnden, Robert G. Bristow, D. Timothy Bishop and Anne E. Kiltie
    Cancer Res September 15 2010 70 (18) 7017-7026; DOI:10.1158/0008-5472.CAN-10-1202

    Findings define a biopsy marker that may predict the type of therapy most likely to cure individual patients of invasive bladder cancer.

Review

Integrated Systems and Technologies

Microenvironment and Immunology

  • Microenvironment and Immunology | Free Article
    The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer
    Erica K. Sloan, Saul J. Priceman, Benjamin F. Cox, Stephanie Yu, Matthew A. Pimentel, Veera Tangkanangnukul, Jesusa M.G. Arevalo, Kouki Morizono, Breanne D.W. Karanikolas, Lily Wu, Anil K. Sood and Steven W. Cole
    Cancer Res September 15 2010 70 (18) 7042-7052; DOI:10.1158/0008-5472.CAN-10-0522

    Metastasis promoted by macrophages may be assisted by the sympathetic nervous system and thus blocked by drugs that antagonize adrenergic signaling.

  • Microenvironment and Immunology
    Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green
    Steven T. Proulx, Paola Luciani, Stefanie Derzsi, Matthias Rinderknecht, Viviane Mumprecht, Jean-Christophe Leroux and Michael Detmar
    Cancer Res September 15 2010 70 (18) 7053-7062; DOI:10.1158/0008-5472.CAN-10-0271

    Quantitative noninvasive imaging of lymphatic flow will greatly assist the study of experimental cancer drugs being developed to target lymphatics, as well as the ability to image lymphedema and sentinel lymph nodes in cancer.

  • Microenvironment and Immunology
    Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases
    Liliana Endo-Munoz, Andrew Cumming, Danny Rickwood, Danielle Wilson, Claudia Cueva, Charlotte Ng, Geoffrey Strutton, A. Ian Cassady, Andreas Evdokiou, Scott Sommerville, Ian Dickinson, Alexander Guminski and Nicholas A. Saunders
    Cancer Res September 15 2010 70 (18) 7063-7072; DOI:10.1158/0008-5472.CAN-09-4291

    Findings suggest that osteoclast-preserving therapies may help prevent or delay metastatic development in osteosarcoma.

  • Microenvironment and Immunology
    Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization
    Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama, Masato Kitazawa, Michiko Takeoka, Kenji Sano, Jun Amano, Zenzo Isogai, Shumpei Niida, Kayoko Oguri, Minoru Okayama, John A. McDonald, Koji Kimata, Shun'ichiro Taniguchi and Naoki Itano
    Cancer Res September 15 2010 70 (18) 7073-7083; DOI:10.1158/0008-5472.CAN-09-4687

    Stromal hyaluronan serves as a microenvironmental signal for recruitment of tumor-associated macrophages, which are key cells involved in tumor neovascularization.

  • Microenvironment and Immunology
    Dacarbazine Treatment before Peptide Vaccination Enlarges T-Cell Repertoire Diversity of Melan-A–Specific, Tumor-Reactive CTL in Melanoma Patients
    Belinda Palermo, Duilia Del Bello, Alessandra Sottini, Federico Serana, Claudia Ghidini, Novella Gualtieri, Virginia Ferraresi, Caterina Catricalà, Filippo Belardelli, Enrico Proietti, Pier Giorgio Natali, Luisa Imberti and Paola Nisticò
    Cancer Res September 15 2010 70 (18) 7084-7092; DOI:10.1158/0008-5472.CAN-10-1326

    Clinical findings support the concept that the use of chemotherapy before a cancer vaccine can promote renewal of tumor-reactive T cells and extend survival.

  • Microenvironment and Immunology
    IFNγ Markedly Cooperates with Intratumoral Dendritic Cell Vaccine in Dog Tumor Models
    Kai Mito, Kikuya Sugiura, Kana Ueda, Takako Hori, Takashi Akazawa, Jyoji Yamate, Hiroshi Nakagawa, Shingo Hatoya, Muneo Inaba, Norimitsu Inoue, Susumu Ikehara and Toshio Inaba
    Cancer Res September 15 2010 70 (18) 7093-7101; DOI:10.1158/0008-5472.CAN-10-0600

    Findings suggest a mechanism through which caveolin-1 can mediate antimetastatic effects in melanoma.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development
    Reginald Hill, Joseph Hargan Calvopina, Christine Kim, Ying Wang, David W. Dawson, Timothy R. Donahue, Sarah Dry and Hong Wu
    Cancer Res September 15 2010 70 (18) 7114-7124; DOI:10.1158/0008-5472.CAN-10-1649

    Cooperation between K-ras activation and PTEN loss during pancreatic carcinogenesis occurs at the early stage of acinar-to-ductal metaplasia.

  • Molecular and Cellular Pathobiology
    hnRNP A2/B1 Modulates Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines
    Jordi Tauler, Enrique Zudaire, Huaitian Liu, Joanna Shih and James L. Mulshine
    Cancer Res September 15 2010 70 (18) 7137-7147; DOI:10.1158/0008-5472.CAN-10-0860

    Findings contribute to growing evidence that modification of hnRNP A2/B1 expression exerts a major impact on the proliferation and invasive capacity of lung cancer cells.

  • Molecular and Cellular Pathobiology
    Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
    Shunbin Xiong, Vinod Pant, Young-Ah Suh, Carolyn S. Van Pelt, Yongxing Wang, Yasmine A. Valentin-Vega, Sean M. Post and Guillermina Lozano
    Cancer Res September 15 2010 70 (18) 7148-7154; DOI:10.1158/0008-5472.CAN-10-1457

    Findings offer preclinical genetic proof that an Mdm2 relative is a critical regulator of p53 and thus a valid therapeutic target to activate p53 in tumors.

  • Molecular and Cellular Pathobiology
    BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma
    Nageatte Ibrahim, Lei He, Chee-Onn Leong, Deyin Xing, Beth Y. Karlan, Elizabeth M. Swisher, Bo R. Rueda, Sandra Orsulic and Leif W. Ellisen
    Cancer Res September 15 2010 70 (18) 7155-7165; DOI:10.1158/0008-5472.CAN-10-0668

    Results define a regulatory mechanism that supports contributions of the p53-related protein p73 as a key mediator of the response to platinum chemotherapy in certain ovarian carcinomas.

  • Molecular and Cellular Pathobiology
    Cyclin-Dependent Kinase–Mediated Phosphorylation Plays a Critical Role in the Oncogenic Functions of PELP1
    Binoj C. Nair, Sujit S. Nair, Dimple Chakravarty, Rambabu Challa, Bramanandam Manavathi, P. Renee Yew, Rakesh Kumar, Rajeshwar Rao Tekmal and Ratna K. Vadlamudi
    Cancer Res September 15 2010 70 (18) 7166-7175; DOI:10.1158/0008-5472.CAN-10-0628

    Results define a key intersection between cell cycle control and estrogen receptor signaling that has implications for breast cancer progression.

  • Molecular and Cellular Pathobiology
    Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway
    Xinna Zhang, Guohui Wan, Sizolwenkosi Mlotshwa, Vicki Vance, Franklin G. Berger, Hexin Chen and Xiongbin Lu
    Cancer Res September 15 2010 70 (18) 7176-7186; DOI:10.1158/0008-5472.CAN-10-0697

    Findings define a mechanism by which a DNA damage-induced microRNA controls a nodal regulator of DNA damage signaling.

Prevention and Epidemiology

  • Prevention and Epidemiology
    Relationship between Radiation Exposure and Risk of Second Primary Cancers among Atomic Bomb Survivors
    Christopher I. Li, Nobuo Nishi, Jean A. McDougall, Erin O. Semmens, Hiromi Sugiyama, Midori Soda, Ritsu Sakata, Mikiko Hayashi, Fumiyoshi Kasagi, Akihiko Suyama, Kiyohiko Mabuchi, Scott Davis, Kazunori Kodama and Kenneth J. Kopecky
    Cancer Res September 15 2010 70 (18) 7187-7198; DOI:10.1158/0008-5472.CAN-10-0276

    Individuals with substantial exposure to radiation who are diagnosed with a first primary cancer should be carefully screened for second primary cancers, particularly those that are radiation sensitive.

Therapeutics, Targets, and Chemical Biology

Tumor and Stem Cell Biology

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