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Table of Contents

Breaking Advances

  • Breaking Advances
    Highlights from Recent Cancer Literature
    Cancer Res September 15 2010 70 (18) 7015-7016; DOI:10.1158/0008-5472.CAN-70-18-BA

Clinical Studies

  • Clinical Studies
    MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer
    Ananya Choudhury, Louisa D. Nelson, Mark T.W. Teo, Sameer Chilka, Selina Bhattarai, Colin F. Johnston, Faye Elliott, Johanna Lowery, Claire F. Taylor, Michael Churchman, Johanne Bentley, Margaret A. Knowles, Patricia Harnden, Robert G. Bristow, D. Timothy Bishop and Anne E. Kiltie
    Cancer Res September 15 2010 70 (18) 7017-7026; DOI:10.1158/0008-5472.CAN-10-1202

    Findings define a biopsy marker that may predict the type of therapy most likely to cure individual patients of invasive bladder cancer.

Review

  • Review
    The Promise of MicroRNA Replacement Therapy
    Andreas G. Bader, David Brown and Matthew Winkler
    Cancer Res September 15 2010 70 (18) 7027-7030; DOI:10.1158/0008-5472.CAN-10-2010

Integrated Systems and Technologies

  • Integrated Systems and Technologies
    Visible Drug Delivery by Supramolecular Nanocarriers Directing to Single-Platformed Diagnosis and Therapy of Pancreatic Tumor Model
    Sachiko Kaida, Horacio Cabral, Michiaki Kumagai, Akihiro Kishimura, Yasuko Terada, Masaki Sekino, Ichio Aoki, Nobuhiro Nishiyama, Toru Tani and Kazunori Kataoka
    Cancer Res September 15 2010 70 (18) 7031-7041; DOI:10.1158/0008-5472.CAN-10-0303

    Study illustrates how cytotoxic nanoparticle therapies can incorporate an approved MRI contrast agent for superior noninvasive imaging in vivo, easing analysis of preclinical and clinical pharmacology.

Microenvironment and Immunology

  • Microenvironment and Immunology | Free Article
    The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer
    Erica K. Sloan, Saul J. Priceman, Benjamin F. Cox, Stephanie Yu, Matthew A. Pimentel, Veera Tangkanangnukul, Jesusa M.G. Arevalo, Kouki Morizono, Breanne D.W. Karanikolas, Lily Wu, Anil K. Sood and Steven W. Cole
    Cancer Res September 15 2010 70 (18) 7042-7052; DOI:10.1158/0008-5472.CAN-10-0522

    Metastasis promoted by macrophages may be assisted by the sympathetic nervous system and thus blocked by drugs that antagonize adrenergic signaling.

  • Microenvironment and Immunology
    Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green
    Steven T. Proulx, Paola Luciani, Stefanie Derzsi, Matthias Rinderknecht, Viviane Mumprecht, Jean-Christophe Leroux and Michael Detmar
    Cancer Res September 15 2010 70 (18) 7053-7062; DOI:10.1158/0008-5472.CAN-10-0271

    Quantitative noninvasive imaging of lymphatic flow will greatly assist the study of experimental cancer drugs being developed to target lymphatics, as well as the ability to image lymphedema and sentinel lymph nodes in cancer.

  • Microenvironment and Immunology
    Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases
    Liliana Endo-Munoz, Andrew Cumming, Danny Rickwood, Danielle Wilson, Claudia Cueva, Charlotte Ng, Geoffrey Strutton, A. Ian Cassady, Andreas Evdokiou, Scott Sommerville, Ian Dickinson, Alexander Guminski and Nicholas A. Saunders
    Cancer Res September 15 2010 70 (18) 7063-7072; DOI:10.1158/0008-5472.CAN-09-4291

    Findings suggest that osteoclast-preserving therapies may help prevent or delay metastatic development in osteosarcoma.

  • Microenvironment and Immunology
    Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization
    Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama, Masato Kitazawa, Michiko Takeoka, Kenji Sano, Jun Amano, Zenzo Isogai, Shumpei Niida, Kayoko Oguri, Minoru Okayama, John A. McDonald, Koji Kimata, Shun'ichiro Taniguchi and Naoki Itano
    Cancer Res September 15 2010 70 (18) 7073-7083; DOI:10.1158/0008-5472.CAN-09-4687

    Stromal hyaluronan serves as a microenvironmental signal for recruitment of tumor-associated macrophages, which are key cells involved in tumor neovascularization.

  • Microenvironment and Immunology
    Dacarbazine Treatment before Peptide Vaccination Enlarges T-Cell Repertoire Diversity of Melan-A–Specific, Tumor-Reactive CTL in Melanoma Patients
    Belinda Palermo, Duilia Del Bello, Alessandra Sottini, Federico Serana, Claudia Ghidini, Novella Gualtieri, Virginia Ferraresi, Caterina Catricalà, Filippo Belardelli, Enrico Proietti, Pier Giorgio Natali, Luisa Imberti and Paola Nisticò
    Cancer Res September 15 2010 70 (18) 7084-7092; DOI:10.1158/0008-5472.CAN-10-1326

    Clinical findings support the concept that the use of chemotherapy before a cancer vaccine can promote renewal of tumor-reactive T cells and extend survival.

  • Microenvironment and Immunology
    IFNγ Markedly Cooperates with Intratumoral Dendritic Cell Vaccine in Dog Tumor Models
    Kai Mito, Kikuya Sugiura, Kana Ueda, Takako Hori, Takashi Akazawa, Jyoji Yamate, Hiroshi Nakagawa, Shingo Hatoya, Muneo Inaba, Norimitsu Inoue, Susumu Ikehara and Toshio Inaba
    Cancer Res September 15 2010 70 (18) 7093-7101; DOI:10.1158/0008-5472.CAN-10-0600

    Findings suggest a mechanism through which caveolin-1 can mediate antimetastatic effects in melanoma.

  • Microenvironment and Immunology
    Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition
    Jason H. Fine, Peter Chen, Aruz Mesci, David S.J. Allan, Stephan Gasser, David H. Raulet and James R. Carlyle
    Cancer Res September 15 2010 70 (18) 7102-7113; DOI:10.1158/0008-5472.CAN-10-1316

    Genotoxic and cell-stressing chemicals sensitize tumor cells to MHC-independent missing-self recognition by NK cells.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development
    Reginald Hill, Joseph Hargan Calvopina, Christine Kim, Ying Wang, David W. Dawson, Timothy R. Donahue, Sarah Dry and Hong Wu
    Cancer Res September 15 2010 70 (18) 7114-7124; DOI:10.1158/0008-5472.CAN-10-1649

    Cooperation between K-ras activation and PTEN loss during pancreatic carcinogenesis occurs at the early stage of acinar-to-ductal metaplasia.

  • Molecular and Cellular Pathobiology
    The Neutrophil Elastase Inhibitor Elafin Triggers Rb-Mediated Growth Arrest and Caspase-Dependent Apoptosis in Breast Cancer
    Joseph A. Caruso, Kelly K. Hunt and Khandan Keyomarsi
    Cancer Res September 15 2010 70 (18) 7125-7136; DOI:10.1158/0008-5472.CAN-10-1547

    Findings suggest applications of a neutrophil protease inhibitor that can attack breast cancer cells without affecting normal proliferating cells.

  • Molecular and Cellular Pathobiology
    hnRNP A2/B1 Modulates Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines
    Jordi Tauler, Enrique Zudaire, Huaitian Liu, Joanna Shih and James L. Mulshine
    Cancer Res September 15 2010 70 (18) 7137-7147; DOI:10.1158/0008-5472.CAN-10-0860

    Findings contribute to growing evidence that modification of hnRNP A2/B1 expression exerts a major impact on the proliferation and invasive capacity of lung cancer cells.

  • Molecular and Cellular Pathobiology
    Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
    Shunbin Xiong, Vinod Pant, Young-Ah Suh, Carolyn S. Van Pelt, Yongxing Wang, Yasmine A. Valentin-Vega, Sean M. Post and Guillermina Lozano
    Cancer Res September 15 2010 70 (18) 7148-7154; DOI:10.1158/0008-5472.CAN-10-1457

    Findings offer preclinical genetic proof that an Mdm2 relative is a critical regulator of p53 and thus a valid therapeutic target to activate p53 in tumors.

  • Molecular and Cellular Pathobiology
    BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma
    Nageatte Ibrahim, Lei He, Chee-Onn Leong, Deyin Xing, Beth Y. Karlan, Elizabeth M. Swisher, Bo R. Rueda, Sandra Orsulic and Leif W. Ellisen
    Cancer Res September 15 2010 70 (18) 7155-7165; DOI:10.1158/0008-5472.CAN-10-0668

    Results define a regulatory mechanism that supports contributions of the p53-related protein p73 as a key mediator of the response to platinum chemotherapy in certain ovarian carcinomas.

  • Molecular and Cellular Pathobiology
    Cyclin-Dependent Kinase–Mediated Phosphorylation Plays a Critical Role in the Oncogenic Functions of PELP1
    Binoj C. Nair, Sujit S. Nair, Dimple Chakravarty, Rambabu Challa, Bramanandam Manavathi, P. Renee Yew, Rakesh Kumar, Rajeshwar Rao Tekmal and Ratna K. Vadlamudi
    Cancer Res September 15 2010 70 (18) 7166-7175; DOI:10.1158/0008-5472.CAN-10-0628

    Results define a key intersection between cell cycle control and estrogen receptor signaling that has implications for breast cancer progression.

  • Molecular and Cellular Pathobiology
    Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway
    Xinna Zhang, Guohui Wan, Sizolwenkosi Mlotshwa, Vicki Vance, Franklin G. Berger, Hexin Chen and Xiongbin Lu
    Cancer Res September 15 2010 70 (18) 7176-7186; DOI:10.1158/0008-5472.CAN-10-0697

    Findings define a mechanism by which a DNA damage-induced microRNA controls a nodal regulator of DNA damage signaling.

Prevention and Epidemiology

  • Prevention and Epidemiology
    Relationship between Radiation Exposure and Risk of Second Primary Cancers among Atomic Bomb Survivors
    Christopher I. Li, Nobuo Nishi, Jean A. McDougall, Erin O. Semmens, Hiromi Sugiyama, Midori Soda, Ritsu Sakata, Mikiko Hayashi, Fumiyoshi Kasagi, Akihiko Suyama, Kiyohiko Mabuchi, Scott Davis, Kazunori Kodama and Kenneth J. Kopecky
    Cancer Res September 15 2010 70 (18) 7187-7198; DOI:10.1158/0008-5472.CAN-10-0276

    Individuals with substantial exposure to radiation who are diagnosed with a first primary cancer should be carefully screened for second primary cancers, particularly those that are radiation sensitive.

  • Prevention and Epidemiology
    Human Papillomavirus Seropositivity Synergizes with MDM2 Variants to Increase the Risk of Oral Squamous Cell Carcinoma
    Xingming Chen, Erich M. Sturgis, Dapeng Lei, Kristina Dahlstrom, Qingyi Wei and Guojun Li
    Cancer Res September 15 2010 70 (18) 7199-7208; DOI:10.1158/0008-5472.CAN-09-4733

    Findings define a genetic marker elevating susceptibility to HPV-associated oral cancers, particularly in never smokers, never drinkers, and oropharyngeal cancer patients.

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology
    Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity
    Zachary C. Hartman, Takuya Osada, Oliver Glass, Xiao Y. Yang, Gang-jun Lei, H. Kim Lyerly and Timothy M. Clay
    Cancer Res September 15 2010 70 (18) 7209-7220; DOI:10.1158/0008-5472.CAN-10-0905

    Ectopic expression of a common TLR adapter signaling protein can exert all the benefits of TLR signaling to antitumor immunity.

  • Therapeutics, Targets, and Chemical Biology
    Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model
    Fei Huang, Warren Hurlburt, Ann Greer, Karen A. Reeves, Stephen Hillerman, Han Chang, Joseph Fargnoli, Friedrich Graf Finckenstein, Marco M. Gottardis and Joan M. Carboni
    Cancer Res September 15 2010 70 (18) 7221-7231; DOI:10.1158/0008-5472.CAN-10-0391

    Study offers the first definition and comparison of acquired resistance mechanisms for IGF-1R targeted therapies.

  • Therapeutics, Targets, and Chemical Biology
    Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3–Activating Compound
    Quinn P. Peterson, Danny C. Hsu, Chris J. Novotny, Diana C. West, Dewey Kim, Joanna M. Schmit, Levent Dirikolu, Paul J. Hergenrother and Timothy M. Fan
    Cancer Res September 15 2010 70 (18) 7232-7241; DOI:10.1158/0008-5472.CAN-10-0766

    Findings demonstrate that direct activation of procaspase-3 by a small molecule can be well tolerated and efficacious as an anticancer strategy.

  • Therapeutics, Targets, and Chemical Biology
    Crucial Roles for Protein Kinase C Isoforms in Tumor-Specific Killing by Apoptin
    Jie Jiang, Daryl Cole, Nigel Westwood, Lee Macpherson, Farzin Farzaneh, Ghulam Mufti, Mahvash Tavassoli and Joop Gäken
    Cancer Res September 15 2010 70 (18) 7242-7252; DOI:10.1158/0008-5472.CAN-10-1204

    Mechanistic studies reveal the basis for a cancer-selective cell death pathway that might be exploited to improve the treatment of multiple myeloma.

  • Therapeutics, Targets, and Chemical Biology
    Colorectal Tumors Are Effectively Eradicated by Combined Inhibition of β-Catenin, KRAS, and the Oncogenic Transcription Factor ITF2
    Luca Mologni, Hafedh Dekhil, Monica Ceccon, Stefania Purgante, Cathy Lan, Loredana Cleris, Vera Magistroni, Franca Formelli and Carlo B. Gambacorti-Passerini
    Cancer Res September 15 2010 70 (18) 7253-7263; DOI:10.1158/0008-5472.CAN-10-1108

    Findings offer preclinical proof of concept for a highly effective combinatorial therapy for colorectal tumors which targets three key oncoproteins.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    Deficiency of Splicing Factor 1 Suppresses the Occurrence of Testicular Germ Cell Tumors
    Rui Zhu, Jason Heaney, Joseph H. Nadeau, Sara Ali and Angabin Matin
    Cancer Res September 15 2010 70 (18) 7264-7272; DOI:10.1158/0008-5472.CAN-10-0820

    Findings strengthen the emerging evidence that alterations in RNA splicing occuring widely in cancer cells functionally contributes to malignant development.

  • Tumor and Stem Cell Biology
    Using the Transcription Factor Inhibitor of DNA Binding 1 to Selectively Target Endothelial Progenitor Cells Offers Novel Strategies to Inhibit Tumor Angiogenesis and Growth
    Albert S. Mellick, Prue N. Plummer, Daniel J. Nolan, Dingcheng Gao, Kathryn Bambino, Mary Hahn, Raul Catena, Vivian Turner, Kevin McDonnell, Robert Benezra, Robert Brink, Alexander Swarbrick and Vivek Mittal
    Cancer Res September 15 2010 70 (18) 7273-7282; DOI:10.1158/0008-5472.CAN-10-1142

    Findings establish a strategy to follow and target bone marrow-derived endothelial progenitor cells that are vital for tumor angiogenesis.

  • Tumor and Stem Cell Biology
    Angiopoietin-4 Promotes Glioblastoma Progression by Enhancing Tumor Cell Viability and Angiogenesis
    Melissa K. Brunckhorst, Hui Wang, Rong Lu and Qin Yu
    Cancer Res September 15 2010 70 (18) 7283-7293; DOI:10.1158/0008-5472.CAN-09-4125

    Findings identify the Ang-4/Tie-2 receptor axis as an attractive therapeutic target to treat aggressive brain cancers.

  • Tumor and Stem Cell Biology
    Cancer-Associated Fibroblasts Enhance the Gland-Forming Capability of Prostate Cancer Stem Cells
    Chun-Peng Liao, Helty Adisetiyo, Mengmeng Liang and Pradip Roy-Burman
    Cancer Res September 15 2010 70 (18) 7294-7303; DOI:10.1158/0008-5472.CAN-09-3982

    Cancer-associated fibroblasts may exert their robust contributions to malignant phenotype by promoting the tumorigenic potential of cancer stem cells.

  • Tumor and Stem Cell Biology
    Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma
    Barbara Dewaele, Giuseppe Floris, Julio Finalet-Ferreiro, Christopher D. Fletcher, Jean-Michel Coindre, Louis Guillou, Pancras C.W. Hogendoorn, Agnieszka Wozniak, Vanessa Vanspauwen, Patrick Schöffski, Peter Marynen, Peter Vandenberghe, Raf Sciot and Maria Debiec-Rychter
    Cancer Res September 15 2010 70 (18) 7304-7314; DOI:10.1158/0008-5472.CAN-10-1543

    Findings suggest that mutationally activated and ligand activated forms of growth factor receptors regulate distinct transcription programs that differentially affect motility, stress response, and stem cell properties.

  • Tumor and Stem Cell Biology
    In vivo Imaging of Tumor Transduced with Bimodal Lentiviral Vector Encoding Human Ferritin and Green Fluorescent Protein on a 1.5T Clinical Magnetic Resonance Scanner
    Hoe Suk Kim, Hye Rim Cho, Seung Hong Choi, Ji Su Woo and Woo Kyung Moon
    Cancer Res September 15 2010 70 (18) 7315-7324; DOI:10.1158/0008-5472.CAN-10-0241

    Simultaneous MRI and fluorescent imaging of tumors can be used to noninvasively monitor metastasis and response to cell or gene-based therapies with the use of an engineered lentiviral system.

  • Tumor and Stem Cell Biology
    A Specific Need for CRKL in p210BCR-ABL–Induced Transformation of Mouse Hematopoietic Progenitors
    Ji-Heui Seo, Lisa J. Wood, Anupriya Agarwal, Thomas O'Hare, Collin R. Elsea, Ian J. Griswold, Michael W.N. Deininger, Akira Imamoto and Brian J. Druker
    Cancer Res September 15 2010 70 (18) 7325-7335; DOI:10.1158/0008-5472.CAN-10-0607

    Results reveal a previously undefined linkage in BCR-ABL effector signaling that is essential to drive transformation of hematopoietic progenitor cells.

  • Tumor and Stem Cell Biology
    Modifying Akt Signaling in B-Cell Chronic Lymphocytic Leukemia Cells
    Sebastian W. Hofbauer, Josefina D. Piñón, Gabriele Brachtl, Lucia Haginger, Wei Wang, Karin Jöhrer, Ingeborg Tinhofer, Tanja Nicole Hartmann and Richard Greil
    Cancer Res September 15 2010 70 (18) 7336-7344; DOI:10.1158/0008-5472.CAN-09-4411

    A survival pathway in chronic lymphocytic leukemia responding to antigenic and stromal support might be targeted by disrupting an Akt pathway mediating this support.

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Cancer Research: 70 (18)
September 2010
Volume 70, Issue 18
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Issue Highlights

  • Visible Drug Delivery by Supramolecular Nanocarriers Directing to Single-Platformed Diagnosis and Therapy of Pancreatic Tumor Model
  • Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity
  • The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer

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Cancer Research Online ISSN: 1538-7445
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