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Table of Contents

Breaking Advances

  • Breaking Advances
    Highlights from Recent Cancer Literature
    Cancer Res November 15 2010 70 (22) 8971-8972; DOI:10.1158/0008-5472.CAN-70-22-BA

Reviews

  • Reviews
    Breast Cancer Stem Cells: Something Out of Notching?
    Hannah Harrison, Gillian Farnie, Keith R. Brennan and Robert B. Clarke
    Cancer Res November 15 2010 70 (22) 8973-8976; DOI:10.1158/0008-5472.CAN-10-1559

  • Reviews
    Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA
    Mo Chen, Jian Zhang and James L. Manley
    Cancer Res November 15 2010 70 (22) 8977-8980; DOI:10.1158/0008-5472.CAN-10-2513

Priority Reports

  • Priority Reports | Free Article
    Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
    Meghan J. Seltzer, Bryson D. Bennett, Avadhut D. Joshi, Ping Gao, Ajit G. Thomas, Dana V. Ferraris, Takashi Tsukamoto, Camilo J. Rojas, Barbara S. Slusher, Joshua D. Rabinowitz, Chi V. Dang and Gregory J. Riggins
    Cancer Res November 15 2010 70 (22) 8981-8987; DOI:10.1158/0008-5472.CAN-10-1666

    IDH1 mutations create a higher dependence of glioma cells on α-ketoglutarate, relative to normal cells, that could be therapeutically exploited by targeting glutamine metabolism.

  • Priority Reports
    Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells
    Jagadish C. Ghosh, Markus D. Siegelin, Takehiko Dohi and Dario C. Altieri
    Cancer Res November 15 2010 70 (22) 8988-8993; DOI:10.1158/0008-5472.CAN-10-2225

    Findings implicate a chaperone network in controlling mitochondrial permeability transition and apoptosis in cancer cells.

Clinical Studies

  • Clinical Studies
    The Ability of Biomarkers to Predict Systemic Progression in Men with High-Risk Prostate Cancer Treated Surgically Is Dependent on ERG Status
    R. Jeffrey Karnes, John C. Cheville, Cristiane M. Ida, Thomas J. Sebo, Asha A. Nair, Hui Tang, Jan-Marie Munz, Farhad Kosari and George Vasmatzis
    Cancer Res November 15 2010 70 (22) 8994-9002; DOI:10.1158/0008-5472.CAN-10-1358

    The study presents TOP2A as a superior prognostic marker for prostate cancer and shows that its predictive ability is dependent on cancer subtype.

  • Clinical Studies
    Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis
    Victoria A. Brown, Ketan R. Patel, Maria Viskaduraki, James A. Crowell, Marjorie Perloff, Tristan D. Booth, Grygoriy Vasilinin, Ananda Sen, Anna Maria Schinas, Gianfranca Piccirilli, Karen Brown, William P. Steward, Andreas J. Gescher and Dean E. Brenner
    Cancer Res November 15 2010 70 (22) 9003-9011; DOI:10.1158/0008-5472.CAN-10-2364

    This study defines suitable doses, accompanying blood levels, and potential efficacy biomarkers which might help to optimize future cancer chemoprevention intervention studies of the red wine constituent resveratrol.

Integrated Systems and Technologies

  • Integrated Systems and Technologies
    Multimodal Mass Spectrometric Imaging of Small Molecules Reveals Distinct Spatio-Molecular Signatures in Differentially Metastatic Breast Tumor Models
    Erika R. Amstalden van Hove, Tiffany R. Blackwell, Ivo Klinkert, Gert B. Eijkel, Ron M.A. Heeren and Kristine Glunde
    Cancer Res November 15 2010 70 (22) 9012-9021; DOI:10.1158/0008-5472.CAN-10-0360

    Mass spectrometry imaging techniques can identify different tissue microenvironments in breast tumors, possibly improving their clinicopathological assessment in the future.

  • Integrated Systems and Technologies
    PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide
    Carsten H. Nielsen, Richard H. Kimura, Nadia Withofs, Phuoc T. Tran, Zheng Miao, Jennifer R. Cochran, Zhen Cheng, Dean Felsher, Andreas Kjær, Juergen K. Willmann and Sanjiv S. Gambhir
    Cancer Res November 15 2010 70 (22) 9022-9030; DOI:10.1158/0008-5472.CAN-10-1338

    Methods that improve PET imaging in cancer offer opportunities for improved detection and management.

Microenvironment and Immunology

  • Microenvironment and Immunology
    Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity
    Sebastian Kreiter, Abderraouf Selmi, Mustafa Diken, Michael Koslowski, Cedrik M. Britten, Christoph Huber, Özlem Türeci and Ugur Sahin
    Cancer Res November 15 2010 70 (22) 9031-9040; DOI:10.1158/0008-5472.CAN-10-0699

    Findings define methods to achieve strong antigen-specific immunity and cancer cures using antigen-encoding RNA in preclinical animal models.

  • Microenvironment and Immunology
    A Therapeutic OX40 Agonist Dynamically Alters Dendritic, Endothelial, and T Cell Subsets within the Established Tumor Microenvironment
    Angela D. Pardee, Dustin McCurry, Sean Alber, Peisheng Hu, Alan L. Epstein and Walter J. Storkus
    Cancer Res November 15 2010 70 (22) 9041-9052; DOI:10.1158/0008-5472.CAN-10-1369

    Correcting tumoral immune escape exerts therapeutic effects against established tumors by improving the delivery of antitumor T cells into the tumor microenvironment.

  • Microenvironment and Immunology
    Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor
    Yangbing Zhao, Edmund Moon, Carmine Carpenito, Chrystal M. Paulos, Xiaojun Liu, Andrea L. Brennan, Anne Chew, Richard G. Carroll, John Scholler, Bruce L. Levine, Steven M. Albelda and Carl H. June
    Cancer Res November 15 2010 70 (22) 9053-9061; DOI:10.1158/0008-5472.CAN-10-2880

    Findings offer preclinical proof-of-concept for a novel adoptive T cell transfer approach for cancer treatment that can potentiate antitumor effects and complement approaches using retroviral and lentiviral engineered T-cell therapies.

  • Microenvironment and Immunology
    Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death
    Roberta Zappasodi, Serenella M. Pupa, Gaia C. Ghedini, Italia Bongarzone, Michele Magni, Antonello D. Cabras, Mario P. Colombo, Carmelo Carlo-Stella, Alessandro M. Gianni and Massimo Di Nicola
    Cancer Res November 15 2010 70 (22) 9062-9072; DOI:10.1158/0008-5472.CAN-10-1825

    Clinical findings confirm expectations of a stringent correlation between the therapeutic efficacy of a dendritic cell vaccine and the extent of immunogenic death induced in the tumor cells used to load the dendritic cells before vaccination.

  • Microenvironment and Immunology
    High-Throughput Characterization of 10 New Minor Histocompatibility Antigens by Whole Genome Association Scanning
    Cornelis A.M. Van Bergen, Caroline E. Rutten, Edith D. Van Der Meijden, Simone A.P. Van Luxemburg-Heijs, Ellie G.A. Lurvink, Jeanine J. Houwing-Duistermaat, Michel G.D. Kester, Arend Mulder, Roel Willemze, J.H. Frederik Falkenburg and Marieke Griffioen
    Cancer Res November 15 2010 70 (22) 9073-9083; DOI:10.1158/0008-5472.CAN-10-1832

    In this study, efficient T-cell selection was combined with SNP genotyping to discover a significant number of new minor histocompatibility antigens that can be targeted by cellular immunotherapy of cancer.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    Critical Roles of DMP1 in Human Epidermal Growth Factor Receptor 2/neu-Arf-p53 Signaling and Breast Cancer Development
    Pankaj Taneja, Dejan Maglic, Fumitake Kai, Takayuki Sugiyama, Robert D. Kendig, Donna P. Frazier, Mark C. Willingham and Kazushi Inoue
    Cancer Res November 15 2010 70 (22) 9084-9094; DOI:10.1158/0008-5472.CAN-10-0159

    Mechanistic findings define a transcriptional cascade that plays a critical role in quenching HER2/neu oncogenic signals known to promote breast cancer.

  • Molecular and Cellular Pathobiology
    Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway
    Tatsuhiro Shibata, Shigeru Saito, Akiko Kokubu, Takafumi Suzuki, Masayuki Yamamoto and Setsuo Hirohashi
    Cancer Res November 15 2010 70 (22) 9095-9105; DOI:10.1158/0008-5472.CAN-10-0384

    Findings offer a rationale to target a master transcriptional regulator of antioxidant genes and Phase II detoxifying enzymes as an anticancer strategy, also suggesting it as a novel theranostic biomarker.

  • Molecular and Cellular Pathobiology
    Insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTOR Signaling
    Reema S. Wahdan-Alaswad, Kyung Song, Tracy L. Krebs, Dorjee T.N. Shola, Jose A. Gomez, Shigemi Matsuyama and David Danielpour
    Cancer Res November 15 2010 70 (22) 9106-9117; DOI:10.1158/0008-5472.CAN-10-1119

    Findings elucidate how a key growth factor in prostate cancer acts at several levels to shut down a central pathway of epithelial cell function in the prostate, with important therapeutic implications for prostate cancer management.

  • Molecular and Cellular Pathobiology
    The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
    Li-hui Wang, Jin Xiang, Min Yan, Yan Zhang, Yan Zhao, Cai-feng Yue, Jie Xu, Fei-meng Zheng, Jin-na Chen, Zhuang Kang, Tong-sheng Chen, Da Xing and Quentin Liu
    Cancer Res November 15 2010 70 (22) 9118-9128; DOI:10.1158/0008-5472.CAN-10-1246

    An important mitotic kinase that is targeted by small molecule inhibitors currently in clinical testing is found to have an important role in supporting metastasis.

  • Molecular and Cellular Pathobiology
    Metabolic Profiling Detects Field Effects in Nondysplastic Tissue from Esophageal Cancer Patients
    Danny Yakoub, Hector C. Keun, Robert Goldin and George B. Hanna
    Cancer Res November 15 2010 70 (22) 9129-9136; DOI:10.1158/0008-5472.CAN-10-1566

    Esophageal cancer can be detected by metabolic profiling of adjacent histologically normal mucosa.

  • Molecular and Cellular Pathobiology
    Dysregulation of the Mitogen Granulin in Human Cancer through the miR-15/107 microRNA Gene Group
    Wang-Xia Wang, Natasha Kyprianou, Xiaowei Wang and Peter T. Nelson
    Cancer Res November 15 2010 70 (22) 9137-9142; DOI:10.1158/0008-5472.CAN-10-1684

    Findings elucidate microRNA-mediated control of a common mitogen in a variety of human cancers, the regulation of which had been previously obscure, with implications for microRNA-based therapeutic targeting.

  • Molecular and Cellular Pathobiology
    Mammalian Target of Rapamycin–Dependent Acinar Cell Neoplasia after Inactivation of Apc and Pten in the Mouse Salivary Gland: Implications for Human Acinic Cell Carcinoma
    Cassandra R. Diegel, Kathleen R. Cho, Adel K. El-Naggar, Bart O. Williams and Charlotta Lindvall
    Cancer Res November 15 2010 70 (22) 9143-9152; DOI:10.1158/0008-5472.CAN-10-1758

    Findings report a novel preclinical model and a rationale to evaluate rapamycin therapy for salivary gland acinic cell carcinoma, a low grade neoplasm but one that tends to recur.

  • Molecular and Cellular Pathobiology
    Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
    Houman Ashrafian, Linda O'Flaherty, Julie Adam, Violetta Steeples, Yuen-Li Chung, Phil East, Sakari Vanharanta, Heli Lehtonen, Emma Nye, Emine Hatipoglu, Melroy Miranda, Kimberley Howarth, Deepa Shukla, Helen Troy, John Griffiths, Bradley Spencer-Dene, Mohammed Yusuf, Emanuela Volpi, Patrick H. Maxwell, Gordon Stamp, Richard Poulsom, Christopher W. Pugh, Barbara Costa, Chiara Bardella, Maria Flavia Di Renzo, Michael I. Kotlikoff, Virpi Launonen, Lauri Aaltonen, Mona El-Bahrawy, Ian Tomlinson and Patrick J. Pollard
    Cancer Res November 15 2010 70 (22) 9153-9165; DOI:10.1158/0008-5472.CAN-10-1949

    Fumarate hydratase deficiency compels cells to prematurely adopt a metabolic phenotype that predisposes them to cell proliferation and growth and ultimately to cancer.

  • Molecular and Cellular Pathobiology
    Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis
    K-John J. Cheung, Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, Ryan D. Morin, Richard Moore, Sohrab P. Shah, Hong Qian, Jessica E. Paul, Adele Telenius, Thomas Relander, Wan Lam, Kerry Savage, Joseph M. Connors, Carolyn Brown, Marco A. Marra, Randy D. Gascoyne and Douglas E. Horsman
    Cancer Res November 15 2010 70 (22) 9166-9174; DOI:10.1158/0008-5472.CAN-10-2460

    Findings identify a candidate genetic marker of prognosis in follicular lymphoma, which may provide an explanation as to why its treatment with rituximab provides less benefit in some patients.

  • Molecular and Cellular Pathobiology
    Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells
    Pedro de Souza Rocha Simonini, Achim Breiling, Nibedita Gupta, Mahdi Malekpour, Mahmoud Youns, Ramesh Omranipour, Fatemeh Malekpour, Stefano Volinia, Carlo M. Croce, Hossein Najmabadi, Sven Diederichs, Özgür Sahin, Doris Mayer, Frank Lyko, Jörg D. Hoheisel and Yasser Riazalhosseini
    Cancer Res November 15 2010 70 (22) 9175-9184; DOI:10.1158/0008-5472.CAN-10-1318

    Findings offer significant new insights into how the estrogen receptor is deregulated in breast cancer.

  • Molecular and Cellular Pathobiology
    Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a
    Jacqueline C. Shultz, Rachel W. Goehe, D. Shanaka Wijesinghe, Charuta Murudkar, Amy J. Hawkins, Jerry W. Shay, John D. Minna and Charles E. Chalfant
    Cancer Res November 15 2010 70 (22) 9185-9196; DOI:10.1158/0008-5472.CAN-10-1545

    Findings define a functionally important alternative splicing mechanism in lung adenocarcinoma that offers a novel approach to therapeutic development.

  • Molecular and Cellular Pathobiology
    Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling
    Yinfei Tan, Mitchell Cheung, Jianming Pei, Craig W. Menges, Andrew K. Godwin and Joseph R. Testa
    Cancer Res November 15 2010 70 (22) 9197-9206; DOI:10.1158/0008-5472.CAN-10-1568

    Findings define a homeobox protein that positively modifies a variety of oncogenic signals in ovarian cancer, with potential prognostic applications.

  • Molecular and Cellular Pathobiology
    Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis
    Yanrong Su, Jarah A. Meador, Gloria M. Calaf, Luca Proietti De-Santis, Yongliang Zhao, Vilhelm A. Bohr and Adayabalam S. Balajee
    Cancer Res November 15 2010 70 (22) 9207-9217; DOI:10.1158/0008-5472.CAN-10-1743

    Study implicates a DNA helicase regulated by Rb-E2F as an important driver of metastatic progression of prostate cancer.

Prevention and Epidemiology

  • Prevention and Epidemiology
    Serum Vitamin D and Risk of Bladder Cancer
    Alison M. Mondul, Stephanie J. Weinstein, Satu Männistö, Kirk Snyder, Ronald L. Horst, Jarmo Virtamo and Demetrius Albanes
    Cancer Res November 15 2010 70 (22) 9218-9223; DOI:10.1158/0008-5472.CAN-10-0985

    Accumulating evidence argues that serum levels of vitamin D exert a profound influence on cancer risk, as illustrated in this study of bladder cancer.

  • Prevention and Epidemiology
    Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer
    Stella Koutros, Laura E. Beane Freeman, Sonja I. Berndt, Gabriella Andreotti, Jay H. Lubin, Dale P. Sandler, Jane A. Hoppin, Kai Yu, Qizhai Li, Laura A. Burdette, Jeffrey Yuenger, Meredith Yeager and Michael C.R. Alavanja
    Cancer Res November 15 2010 70 (22) 9224-9233; DOI:10.1158/0008-5472.CAN-10-1078

    Study offers an excellent illustration of how an environmental modifier can radically alter the impact of a genetic risk marker on a patient's susceptibilty to disease.

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology
    Ki-67 as a Molecular Target for Therapy in an In vitro Three-Dimensional Model for Ovarian Cancer
    Ramtin Rahmanzadeh, Prakash Rai, Jonathan P. Celli, Imran Rizvi, Bettina Baron-Lühr, Johannes Gerdes and Tayyaba Hasan
    Cancer Res November 15 2010 70 (22) 9234-9242; DOI:10.1158/0008-5472.CAN-10-1190

    A common immunohistopathological marker used for staging of clinical cancers may offer unexpected opportunities as a therapeutic target.

  • Therapeutics, Targets, and Chemical Biology
    MGMT-Independent Temozolomide Resistance in Pediatric Glioblastoma Cells Associated with a PI3-Kinase–Mediated HOX/Stem Cell Gene Signature
    Nathalie Gaspar, Lynley Marshall, Lara Perryman, Dorine A. Bax, Suzanne E. Little, Marta Viana-Pereira, Swee Y. Sharp, Gilles Vassal, Andrew D.J. Pearson, Rui M. Reis, Darren Hargrave, Paul Workman and Chris Jones
    Cancer Res November 15 2010 70 (22) 9243-9252; DOI:10.1158/0008-5472.CAN-10-1250

    Findings identify a reversible novel mechanism of resistance to the alkylating agent temozolomide in pediatric glioblastoma model systems and patient samples.

  • Therapeutics, Targets, and Chemical Biology
    Class III β-Tubulin Expression Predicts Prostate Tumor Aggressiveness and Patient Response to Docetaxel-Based Chemotherapy
    Guillaume Ploussard, Stéphane Terry, Pascale Maillé, Yves Allory, Nanor Sirab, Laurence Kheuang, Pascale Soyeux, Nathalie Nicolaiew, Estelle Coppolani, Bernard Paule, Laurent Salomon, Stéphane Culine, Ralph Buttyan, Francis Vacherot and Alexandre de la Taille
    Cancer Res November 15 2010 70 (22) 9253-9264; DOI:10.1158/0008-5472.CAN-10-1447

    Findings suggest a novel theranostic molecule in advanced prostate cancer to predict responses to taxane therapy and to improve treatment of taxane-resistant disease.

  • Therapeutics, Targets, and Chemical Biology
    Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
    Vaibhav Kapuria, Luke F. Peterson, Dexing Fang, William G. Bornmann, Moshe Talpaz and Nicholas J. Donato
    Cancer Res November 15 2010 70 (22) 9265-9276; DOI:10.1158/0008-5472.CAN-10-1530

    An antitumor compound previously found to block signaling by Jak2 kinase is found to target deubiquitinases that are commonly overexpressed in cancer cells.

  • Therapeutics, Targets, and Chemical Biology | Free Article
    Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
    Freddy E. Escorcia, Erik Henke, Michael R. McDevitt, Carlos H. Villa, Peter Smith-Jones, Ronald G. Blasberg, Robert Benezra and David A. Scheinberg
    Cancer Res November 15 2010 70 (22) 9277-9286; DOI:10.1158/0008-5472.CAN-10-2029

    A novel approach to remodel the tumor vasculature has strongly positive pharmacokinetic consequences on cancer drug delivery in a preclinical model, resulting in better therapy and survival outcomes.

  • Therapeutics, Targets, and Chemical Biology
    Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy
    Youyou Zhao, Declan McLaughlin, Emma Robinson, Adam P. Harvey, Michelle B. Hookham, Ajay M. Shah, Barbara J. McDermott and David J. Grieve
    Cancer Res November 15 2010 70 (22) 9287-9297; DOI:10.1158/0008-5472.CAN-10-2664

    A major ROS-producing enzyme in the heart is implicated in adverse cardiac remodeling caused by doxorubicin chemotherapy, implying a new therapeutic strategy to reduce doxorubicin cardiotoxicity.

  • Therapeutics, Targets, and Chemical Biology
    WNT11 Expression Is Induced by Estrogen-Related Receptor α and β-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration
    Mary A. Dwyer, James D. Joseph, Hilary E. Wade, Matthew L. Eaton, Rebecca S. Kunder, Dmitri Kazmin, Ching-yi Chang and Donald P. McDonnell
    Cancer Res November 15 2010 70 (22) 9298-9308; DOI:10.1158/0008-5472.CAN-10-0226

    Results define an autocrine mechanism controlled by the nuclear receptor ERRα, associated with poor outcomes in several cancers, that influences cancer cell migratory capacity.

  • Therapeutics, Targets, and Chemical Biology
    Induction of DNA Damage-Inducible Gene GADD45β Contributes to Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Cells
    Da-Liang Ou, Ying-Chun Shen, Sung-Liang Yu, Kuen-Feng Chen, Pei-Yen Yeh, Hsiang-Hsuan Fan, Wen-Chi Feng, Ching-Tzu Wang, Liang-In Lin, Chiun Hsu and Ann-Lii Cheng
    Cancer Res November 15 2010 70 (22) 9309-9318; DOI:10.1158/0008-5472.CAN-10-1033

    Mechanistic findings suggest a potential surrogate marker that could be useful to predict the efficacy of Sorafenib in liver cancer.

  • Therapeutics, Targets, and Chemical Biology
    Synergistic Enhancement of Carboplatin Efficacy with Photodynamic Therapy in a Three-Dimensional Model for Micrometastatic Ovarian Cancer
    Imran Rizvi, Jonathan P. Celli, Conor L. Evans, Adnan O. Abu-Yousif, Alona Muzikansky, Brian W. Pogue, Dianne Finkelstein and Tayyaba Hasan
    Cancer Res November 15 2010 70 (22) 9319-9328; DOI:10.1158/0008-5472.CAN-10-1783

    A 3D model for ovarian micrometastases is introduced as a high-throughput platform to report treatment response, exemplified in this study to show how photodynamic therapy synergistically enhances carboplatin efficacy.

  • Therapeutics, Targets, and Chemical Biology
    Voluntary Running Prevents Progressive Memory Decline and Increases Adult Hippocampal Neurogenesis and Growth Factor Expression after Whole-Brain Irradiation
    Sarah J.E. Wong-Goodrich, Madeline L. Pfau, Catherine T. Flores, Jennifer A. Fraser, Christina L. Williams and Lee W. Jones
    Cancer Res November 15 2010 70 (22) 9329-9338; DOI:10.1158/0008-5472.CAN-10-1854

    Studies in mice suggest that voluntary exercise can alleviate progressive memory loss after cranial irradiation, strongly prompting studies in clinical settings.

  • Therapeutics, Targets, and Chemical Biology
    Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery
    Shinji Kuroda, Toshiya Fujiwara, Yasuhiro Shirakawa, Yasumoto Yamasaki, Shuya Yano, Futoshi Uno, Hiroshi Tazawa, Yuuri Hashimoto, Yuichi Watanabe, Kazuhiro Noma, Yasuo Urata, Shunsuke Kagawa and Toshiyoshi Fujiwara
    Cancer Res November 15 2010 70 (22) 9339-9348; DOI:10.1158/0008-5472.CAN-10-2333

    Results illustrate the potential of combining engineered oncolytic virotherapy and ionizing radiation as a strategy to improve the management of human cancer.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    Brick1 Is an Essential Regulator of Actin Cytoskeleton Required for Embryonic Development and Cell Transformation
    Beatriz Escobar, Guillermo de Cárcer, Gonzalo Fernández-Miranda, Alberto Cascón, José J. Bravo-Cordero, María C. Montoya, Mercedes Robledo, Marta Cañamero and Marcos Malumbres
    Cancer Res November 15 2010 70 (22) 9349-9359; DOI:10.1158/0008-5472.CAN-09-4491

    Genetic ablation of Brick1, a component of the Wave/Scar actin regulatory complex, appears to exert a protective effect against malignant development in renal cancer and other cancers where loss occurs.

  • Tumor and Stem Cell Biology
    mTOR Complex Component Rictor Interacts with PKCζ and Regulates Cancer Cell Metastasis
    Fei Zhang, Xiaofang Zhang, Menghui Li, Peng Chen, Bin Zhang, Hua Guo, Wenfeng Cao, Xiying Wei, Xuchen Cao, Xishan Hao and Ning Zhang
    Cancer Res November 15 2010 70 (22) 9360-9370; DOI:10.1158/0008-5472.CAN-10-0207

    Findings illuminate understanding of how EGF activates the mTORC2 growth regulatory complex to drive breast cancer metastasis, with implications for clinical studies of mTOR inhibitors.

  • Tumor and Stem Cell Biology
    Surface-Immobilized Aptamers for Cancer Cell Isolation and Microscopic Cytology
    Yuan Wan, Young-tae Kim, Na Li, Steve K. Cho, Robert Bachoo, Andrew D. Ellington and Samir M. Iqbal
    Cancer Res November 15 2010 70 (22) 9371-9380; DOI:10.1158/0008-5472.CAN-10-0568

    More sensitive and specific tumor detection technologies are needed to rapidly assess surgical resection margins and to monitor residual tumor cells that may persist in blood after disease treatment.

  • Tumor and Stem Cell Biology
    Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo
    Shinji Takeuchi, Akiko Takahashi, Noriko Motoi, Shin Yoshimoto, Tomoko Tajima, Kimi Yamakoshi, Atsushi Hirao, Shigeru Yanagi, Kiyoko Fukami, Yuichi Ishikawa, Saburo Sone, Eiji Hara and Naoko Ohtani
    Cancer Res November 15 2010 70 (22) 9381-9390; DOI:10.1158/0008-5472.CAN-10-0801

    Expectations that mice lacking both the p16INK4 and p21WAF1 tumor suppressor genes would be highly susceptible to carcinogenesis is experimentally confirmed and mechanistically dissected in this study.

  • Tumor and Stem Cell Biology
    Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells
    Falko Hochgräfe, Luxi Zhang, Sandra A. O'Toole, Brigid C. Browne, Mark Pinese, Ana Porta Cubas, Gillian M. Lehrbach, David R. Croucher, Danny Rickwood, Alice Boulghourjian, Robert Shearer, Radhika Nair, Alexander Swarbrick, Dana Faratian, Peter Mullen, David J. Harrison, Andrew V. Biankin, Robert L. Sutherland, Mark J. Raftery and Roger J. Daly
    Cancer Res November 15 2010 70 (22) 9391-9401; DOI:10.1158/0008-5472.CAN-10-0911

    Phosphoproteomic profiling reveals that basal breast cancer cells are characterized by an extensive Src family kinase signalling network, highlighting candidate theranostic targets for this aggresive subtype of breast cancers.

  • Tumor and Stem Cell Biology
    ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2
    Ekaterina V. Kalashnikova, Alexey S. Revenko, Abigael T. Gemo, Nicolas P. Andrews, Clifford G. Tepper, June X. Zou, Robert D. Cardiff, Alexander D. Borowsky and Hong-Wu Chen
    Cancer Res November 15 2010 70 (22) 9402-9412; DOI:10.1158/0008-5472.CAN-10-1199

    Findings suggest that the prognostic significance of a chromatin coregulator for hormone receptors in breast cancer is based on its role in integrating multiple oncogenic programs, with particular importance to aggressive triple-negative tumors.

  • Tumor and Stem Cell Biology
    Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics
    Marta Canel, Alan Serrels, Derek Miller, Paul Timpson, Bryan Serrels, Margaret C. Frame and Valerie G. Brunton
    Cancer Res November 15 2010 70 (22) 9413-9422; DOI:10.1158/0008-5472.CAN-10-1454

    Results identify a novel role for FAK and Src in regulating tumor cell movement in vivo using fluorescence based microscopy.

  • Tumor and Stem Cell Biology
    Hepatocyte Nuclear Factor-4α Promotes Gut Neoplasia in Mice and Protects against the Production of Reactive Oxygen Species
    Mathieu Darsigny, Jean-Philippe Babeu, Ernest G. Seidman, Fernand-Pierre Gendron, Emile Levy, Julie Carrier, Nathalie Perreault and François Boudreau
    Cancer Res November 15 2010 70 (22) 9423-9433; DOI:10.1158/0008-5472.CAN-10-1697

    Findings point to the nuclear receptor HNF4α as a potential therapeutic target to modify epithelial cell resistance to ROS production during intestinal tumorigenesis.

  • Tumor and Stem Cell Biology
    Clld7, A Candidate Tumor Suppressor on Chromosome 13q14, Regulates Pathways of DNA Damage/Repair and Apoptosis
    Xiaobo Zhou and Karl Münger
    Cancer Res November 15 2010 70 (22) 9434-9443; DOI:10.1158/0008-5472.CAN-10-1960

    Findings support the definition of a new tumor suppressor located at chromosome 13q14 and suggest its possible utility in predicting cancer chemosensitivity.

  • Tumor and Stem Cell Biology
    Tumor-Initiating Function of Nucleostemin-Enriched Mammary Tumor Cells
    Tao Lin, Lingjun Meng, Yi Li and Robert Y.L. Tsai
    Cancer Res November 15 2010 70 (22) 9444-9452; DOI:10.1158/0008-5472.CAN-10-2159

    Studies of a stem cell marker in breast cancer cells suggest its potential as a therapeutic target.

  • Tumor and Stem Cell Biology
    Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development
    Nicolas Willemarck, Evelien Rysman, Koen Brusselmans, Griet Van Imschoot, Frank Vanderhoydonc, Katrien Moerloose, Evelyne Lerut, Guido Verhoeven, Frans van Roy, Kris Vleminckx and Johannes V. Swinnen
    Cancer Res November 15 2010 70 (22) 9453-9462; DOI:10.1158/0008-5472.CAN-10-2324

    Findings suggest that characteristic elevations in lipogenesis in cancer cells contribute to tumor growth not by improving membrane biosynthesis, as commonly believed, but by modifying fundamental developmental signaling and cell polarity.

  • Tumor and Stem Cell Biology
    Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells
    Xiaojun Yang, Xiaojuan Lin, Xiaomin Zhong, Sippy Kaur, Ning Li, Shun Liang, Heini Lassus, Liping Wang, Dionyssios Katsaros, Kathleen Montone, Xia Zhao, Youcheng Zhang, Ralf Bützow, George Coukos and Lin Zhang
    Cancer Res November 15 2010 70 (22) 9463-9472; DOI:10.1158/0008-5472.CAN-10-2388

    Findings offer evidence that cancer stem cells may arise through cellular reprogramming-like mechanisms.

  • Tumor and Stem Cell Biology
    MicroRNA miR-302 Inhibits the Tumorigenecity of Human Pluripotent Stem Cells by Coordinate Suppression of the CDK2 and CDK4/6 Cell Cycle Pathways
    Shi-Lung Lin, Donald C. Chang, Shao-Yao Ying, Davey Leu and David T.S. Wu
    Cancer Res November 15 2010 70 (22) 9473-9482; DOI:10.1158/0008-5472.CAN-10-2746

    As the most abundant tumor suppressor microRNA in human embryonic stem cells, miR-302 offers an appealing focus for the development of a universal cancer therapeutic.

  • Tumor and Stem Cell Biology
    Silencing of Autocrine Motility Factor Induces Mesenchymal-to-Epithelial Transition and Suppression of Osteosarcoma Pulmonary Metastasis
    Yasufumi Niinaka, Kiyoshi Harada, Masahiro Fujimuro, Masamitsu Oda, Arayo Haga, Misa Hosoki, Narikazu Uzawa, Naoya Arai, Satoshi Yamaguchi, Masashi Yamashiro and Avraham Raz
    Cancer Res November 15 2010 70 (22) 9483-9493; DOI:10.1158/0008-5472.CAN-09-3880

    An enzyme that functions inside cells in glycolysis and gluconeogenesis has a second extracellular function that in cancer provides a critical support for invasive cell motility, EMT, and metastasis.

  • Tumor and Stem Cell Biology
    The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines
    Immanual Joseph, Robert Tressler, Ekaterina Bassett, Calvin Harley, Christen M. Buseman, Preeti Pattamatta, Woodring E. Wright, Jerry W. Shay and Ning F. Go
    Cancer Res November 15 2010 70 (22) 9494-9504; DOI:10.1158/0008-5472.CAN-10-0233

    Findings offer preclinical proof-of-concept for a highly tractable and attractive new approach to target cancer stem cells in cancer therapy.

  • Tumor and Stem Cell Biology
    Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation
    Pankaj Kumar Mandal, Manuela Schneider, Pirkko Kölle, Peter Kuhlencordt, Heidi Förster, Heike Beck, Georg W. Bornkamm and Marcus Conrad
    Cancer Res November 15 2010 70 (22) 9505-9514; DOI:10.1158/0008-5472.CAN-10-1509

    Findings offer preclinical proof-of-concept that simultaneous inhibition of more than one cellular antioxidant system could be highly effective in killing tumor cells via redox modifiers.

  • Tumor and Stem Cell Biology
    Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1
    Emilios Gemenetzidis, Daniela Elena-Costea, Eric K. Parkinson, Ahmad Waseem, Hong Wan and Muy-Teck Teh
    Cancer Res November 15 2010 70 (22) 9515-9526; DOI:10.1158/0008-5472.CAN-10-2173

    Results identify a transcription factor in the FOXM1 family that can hijack adult human stem cells to jump start cancer initiation.

Corrections

  • Corrections
    Correction: Curcumin Blocks RON Tyrosine Kinase–Mediated Invasion of Breast Carcinoma Cells
    Cancer Res November 15 2010 70 (22) 9527-9527; DOI:10.1158/0008-5472.CAN-10-3495

  • Corrections
    Correction: RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models
    Cancer Res November 15 2010 70 (22) 9527-9527; DOI:10.1158/0008-5472.CAN-10-3605

Retractions

  • Retractions
    Retraction: Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity
    Cancer Res November 15 2010 70 (22) 9528-9528; DOI:10.1158/0008-5472.CAN-10-3461

  • Retractions
    Retraction: An Effective Vaccine Strategy Protective against Antigenically Distinct Tumor Variants
    Cancer Res November 15 2010 70 (22) 9528-9528; DOI:10.1158/0008-5472.CAN-10-3462

  • Retractions
    Retraction: CTL Activation Using the Natural Low-Affinity Epitope 222-229 from Tyrosinase-Related Protein 1 Leads to Tumor Rejection
    Cancer Res November 15 2010 70 (22) 9529-9529; DOI:10.1158/0008-5472.CAN-10-3463

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Cancer Research: 70 (22)
November 2010
Volume 70, Issue 22
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Issue Highlights

  • Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity
  • Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death
  • Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors

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  • Extracellular Citrate and Cancer Metabolism
  • Tau Mutations as a Novel Risk Factor for Cancer
  • PP2A Activation for the Treatment of Prostate Cancer
  • FIH Hydroxylates and Inactivates G9a and GLP
  • Abstract 5243: Prognostic value of nuclear and non-nuclear estrogen receptor expression by immunohistochemistry with phosphor-integrated dots in hormone receptor-positive early breast cancer
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Cancer Research Online ISSN: 1538-7445
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